N-acetylcysteine stimulates organelle malfunction in endometriotic cells via IFN-gamma signaling
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-00195-z
Abstract: Endometriosis is a chronic inflammatory gynecologic disease characterized by the abnormal implantation of endometrial tissue outside the uterus. The inflammatory microenvironment of endometriosis is dominated by highly migratory endometriotic cells, inflammatory cells, and cytokines. There… read more here.
Keywords: malfunction endometriotic; organelle malfunction; endometriotic cells; endometriosis ... See more keywords
Activin A Modulates Betaglycan Shedding via the ALK4-SMAD3-Dependent Pathway in Endometriotic Cells
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DOI: 10.3390/biom12121749
Abstract: The TGF-β superfamily members, activins and inhibins, are mainly involved in cell proliferation, cell survival, invasion, immune surveillance, and lesion growth in endometriosis. Herein, we investigated the modulation of the TGF-β type III receptor (betaglycan… read more here.
Keywords: activin modulates; activin; endometriotic cells; effects activin ... See more keywords
Resveratrol and Its Natural Analogs Mitigate Immune Dysregulation and Oxidative Imbalance in the Endometriosis Niche Simulated in a Co-Culture System of Endometriotic Cells and Macrophages
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DOI: 10.3390/nu16203483
Abstract: Background: Inflammation and immune cell dysfunction are critical facilitators of endometriosis pathophysiology. Macrophages are renowned for stimulating lesion growth, vascularization, innervation, and pain generation. By combining macrophages and endometriotic cells, we determined if resveratrol and… read more here.
Keywords: immune dysregulation; culture; endometriotic cells; endometriosis ... See more keywords