Impact of Bevacizumab on Experimentally Induced Endometriotic Lesions: Angiogenesis, Invasion, Apoptosis, and Cell Proliferation
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-020-00213-7
Abstract: Endometriosis is responsible for pain symptoms with great impact on the patient’s quality of life. Several medication lines have been studied aiming at its definitive treatment. Among them, angiogenesis inhibitor factors may be effective given… read more here.
Keywords: cell proliferation; bevacizumab; endometriotic lesions; endometriosis ... See more keywords
Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development.
Sign Up to like & getrecommendations! Published in 2018 at "Fertility and sterility"
DOI: 10.1016/j.fertnstert.2018.08.016
Abstract: OBJECTIVE To study the mechanisms of invasion and innervation of deep endometriosis in women. DESIGN Morphologic and immunohistochemical analysis of human endometriotic lesions. SETTING Academic research unit. PATIENT(S) Seventeen biopsy samples of deep endometriotic lesions… read more here.
Keywords: endometriotic lesions; invasion; cell migration; collective cell ... See more keywords
Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions
Sign Up to like & getrecommendations! Published in 2022 at "Geburtshilfe und Frauenheilkunde"
DOI: 10.1055/a-1580-0601
Abstract: Abstract Objectives Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic… read more here.
Keywords: mitotic figures; endometriosis; endometriotic lesions; group ... See more keywords
Differences in growth and vascularization of ectopic menstrual and non-menstrual endometrial tissue in mouse models of endometriosis.
Sign Up to like & getrecommendations! Published in 2021 at "Human reproduction"
DOI: 10.1093/humrep/deab139
Abstract: STUDY QUESTION Is there a difference in the growth and vascularization between murine endometriotic lesions originating from menstrual or non-menstrual endometrial fragments? SUMMARY ANSWER Endometriotic lesions developing from menstrual and non-menstrual tissue fragments share many… read more here.
Keywords: endometriosis; endometriotic lesions; tissue; non menstrual ... See more keywords
Basic mechanisms of vascularization in endometriosis and their clinical implications
Sign Up to like & getrecommendations! Published in 2018 at "Human Reproduction Update"
DOI: 10.1093/humupd/dmy001
Abstract: BACKGROUND Vascularization is a major hallmark in the pathogenesis of endometriosis. An increasing number of studies suggests that multiple mechanisms contribute to the vascularization of endometriotic lesions, including angiogenesis, vasculogenesis and inosculation. OBJECTIVE AND RATIONALE… read more here.
Keywords: basic mechanisms; endometriosis; endometriotic lesions; vascularization ... See more keywords
Spheroids as a model for endometriotic lesions.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.160815
Abstract: The development and progression of endometriotic lesions are poorly understood, but immune cell dysfunction and inflammation are closely associated with the pathophysiology of endometriosis. There is a need for 3D in vitro models to permit… read more here.
Keywords: development; endometriotic lesions; spheroids model; model endometriotic ... See more keywords
Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.961599
Abstract: Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other… read more here.
Keywords: estrogen; mast; endometriotic lesions; mast cells ... See more keywords
Higher Oxidative Stress in Endometriotic Lesions Upregulates Senescence-Associated p16ink4a and β-Galactosidase in Stromal Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24020914
Abstract: Endometriosis affects a significant proportion of women worldwide; however, no definitive cure for this disease has been discovered to date. Oxidative stress promotes endometriotic lesion maintenance in the peritoneal cavity in women. Furthermore, there is… read more here.
Keywords: endometriosis; oxidative stress; endometriotic lesions; senescence ... See more keywords
Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14224940
Abstract: Endometriosis represents an estrogen-dependent disorder with a complex pathophysiology. Phytochemicals are promising candidates for endometriosis therapy, because they simultaneously target different cellular processes involved in the pathogenesis of endometriosis. Herein, we analyzed whether indole-3-carbinol (I3C)… read more here.
Keywords: growth; endometriotic lesions; formation; i3c ... See more keywords