HIGLE is a bifunctional homing endonuclease that directly interacts with HYL1 and SERRATE in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12628
Abstract: A highly coordinated complex known as the microprocessor precisely processes primary transcripts of MIRNA genes into mature miRNAs. In plants, the microprocessor minimally consists of three components: Dicer‐like protein 1 (DCL1), HYPONASTIC LEAF 1 (HYL1),… read more here.
Keywords: giy yig; endonuclease; homing; hyl1 serrate ... See more keywords
Death by translation: ribosome‐assisted degradation of mRNA by endonuclease toxins
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12715
Abstract: Like other forms of life, bacteria utilize a variety of mechanisms to survive stress. Some of these mechanisms mitigate the physiological impact of the stress, whereas others enable cells to simply wait out the stressful… read more here.
Keywords: endonuclease; yhav; stress; toxin ... See more keywords
Multiple zinc ions maintain the open conformation of the catalytic site in the DNA mismatch repair endonuclease MutL from Aquifex aeolicus
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13050
Abstract: The DNA mismatch repair endonuclease MutL consists of N‐terminal ATPase and C‐terminal endonuclease domains. The endonuclease domain binds zinc ion, although the ion seems not to function as a catalytic metal ion. Here, we solved… read more here.
Keywords: endonuclease; dna mismatch; zinc; mutl ... See more keywords
8‐Hydroxy‐1,6‐naphthyridine‐7‐carboxamides as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202200334
Abstract: Human cytomegalovirus (HCMV) replication requires a metal‐dependent endonuclease at the C‐terminus of pUL89 (pUL89‐C) for viral genome packaging and cleavage. We have previously shown that pUL89‐C can be pharmacologically inhibited with designed metal‐chelating compounds. We… read more here.
Keywords: pul89; human cytomegalovirus; hydroxy naphthyridine; endonuclease ... See more keywords
Behavior of BsoBI endonuclease in the presence and absence of DNA
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-017-3557-8
Abstract: BsoBI is a type II restriction endonuclease belonging to the EcoRI family. There is only one previously published X-ray structure for this endonuclease: it shows a homodimer of BsoBI completely encircling DNA in a tunnel.… read more here.
Keywords: endonuclease; behavior bsobi; dna; endonuclease presence ... See more keywords
Endonuclease G modulates the alternative splicing of deoxyribonuclease 1 mRNA in human CD4+ T lymphocytes and prevents the progression of apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2018.11.020
Abstract: Apoptotic endonucleases act cooperatively to fragment DNA and ensure the irreversibility of apoptosis. However, very little is known regarding the potential regulatory links between endonucleases. Deoxyribonuclease 1 (DNase I) inactivation is caused by alternative splicing… read more here.
Keywords: endonuclease; dnase; apoptosis; endog ... See more keywords
Facile and sensitive S1 endonuclease activity and inhibition assay using positively-charged Ag nanorods
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2018.11.017
Abstract: Abstract In this work, we designed a facile and promising strategy for fluorescence determination of S1 endonuclease activity and inhibition based on fluorescence resonance energy transfer (FRET) between positively Ag nanorods (AgNRs) and negatively-charged ROX-labeled… read more here.
Keywords: endonuclease; fluorescence; rox ssdna; activity inhibition ... See more keywords
Biochemical characterization of mismatch-binding protein MutS1 and nicking endonuclease MutL from a euryarchaeon Methanosaeta thermophila.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.01.005
Abstract: In eukaryotes and most bacteria, the MutS1/MutL-dependent mismatch repair system (MMR) corrects DNA mismatches that arise as replication errors. MutS1 recognizes mismatched DNA and stimulates the nicking endonuclease activity of MutL to incise mismatch-containing DNA.… read more here.
Keywords: endonuclease; nicking endonuclease; muts1 mutl; mutl ... See more keywords
Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.06.046
Abstract: Endonuclease V (EndoV) cleaves the second phosphodiester bond 3' to a deaminated adenosine (inosine). Although highly conserved, EndoV homologs change substrate preference from DNA in bacteria to RNA in eukaryotes. We have characterized EndoV from… read more here.
Keywords: endonuclease; inosine specific; endov homologs; inosine ... See more keywords
Development of an Endonuclease V-Assisted Analytical Method for Sequencing Analysis of Deoxyinosine in DNA.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02126
Abstract: Deoxyinosine (dI) is a highly mutagenic lesion that preferentially pairs with deoxycytidine during replication, which may induce A to G transition and ultimately contribute to carcinogenesis. Therefore, finding the site of dI modification in DNA… read more here.
Keywords: modification; dna; sequencing analysis; endonuclease ... See more keywords
Alkyne-DNA-Functionalized Alloyed Au/Ag Nanospheres for Ratiometric Surface-Enhanced Raman Scattering Imaging Assay of Endonuclease Activity in Live Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b04735
Abstract: A novel ratiometric surface-enhanced Raman scattering (SERS) nanosensor has been developed to probe the activity of endonuclease under in vitro and in living cells conditions. The optimized alloyed Au/Ag nanoparticles (NPs) were synthesized as the… read more here.
Keywords: endonuclease; surface enhanced; enhanced raman; surface ... See more keywords