Metal‐chelating 3‐hydroxypyrimidine‐2,4‐diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.01.015
Abstract: ABSTRACT Human cytomegalovirus terminase complex cleaves the concatemeric genomic viral DNA into unit lengths during genome packaging and particle assembly. Terminase complex ATPase and endonuclease activity is provided by the viral protein pUL89. pUL89 is… read more here.
Keywords: endonuclease activity; replication; pul89; hydroxypyrimidine diones ... See more keywords
Facile and sensitive S1 endonuclease activity and inhibition assay using positively-charged Ag nanorods
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2018.11.017
Abstract: Abstract In this work, we designed a facile and promising strategy for fluorescence determination of S1 endonuclease activity and inhibition based on fluorescence resonance energy transfer (FRET) between positively Ag nanorods (AgNRs) and negatively-charged ROX-labeled… read more here.
Keywords: endonuclease; fluorescence; rox ssdna; activity inhibition ... See more keywords
Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells.
Sign Up to like & getrecommendations! Published in 2019 at "Nanoscale"
DOI: 10.1039/c9nr06436b
Abstract: A highly sensitive enzyme-free amplification assay for the detection of apurinic/apyrimidinic endonuclease 1 activity was developed. By incorporating biodegradable MnO2 nanosheets, in situ light up intracellular APE 1 activity was achieved. read more here.
Keywords: endonuclease activity; biodegradable mno2; apurinic apyrimidinic; activity ... See more keywords
Targeted inhibition of the endonuclease activity of influenza polymerase acidic proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2021-0264
Abstract: Influenza is a type of acute respiratory virus infection caused by the influenza virus that occurs in epidemics worldwide every year. Due to the increasing incidence of influenza virus resistance to existing drugs, researchers are looking for… read more here.
Keywords: influenza virus; virus; endonuclease activity; polymerase acidic ... See more keywords