Illuminating the membrane contact sites between the endoplasmic reticulum and the trans‐Golgi network
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13639
Abstract: Membrane contact sites (MCSs) between different organelles have been identified and extensively studied over the last decade. Several classes of MCSs have now well‐established roles, although the contacts between the endoplasmic reticulum (ER) and the… read more here.
Keywords: membrane contact; endoplasmic reticulum; golgi network; contact sites ... See more keywords
The role of sphingolipids in endoplasmic reticulum stress
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13863
Abstract: The endoplasmic reticulum (ER) is an important intracellular compartment in eukaryotic cells and has diverse functions, including protein synthesis, protein folding, lipid metabolism and calcium homeostasis. ER functions are disrupted by various intracellular and extracellular… read more here.
Keywords: endoplasmic reticulum; role sphingolipids; reticulum stress; stress ... See more keywords
Diacylglycerol kinase alleviates autophagic degradation of the endoplasmic reticulum in SPT10‐deficient yeast to enhance triterpene biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14418
Abstract: A recent study showed that deletion of the gene encoding the transcription regulator SuPpressor of Ty10 (SPT10) increases total phospholipids, and our previous study established a critical link between phospholipids and the mevalonate/ergosterol (MEV/ERG) pathway,… read more here.
Keywords: endoplasmic reticulum; triterpene; spt10; spt10 yeast ... See more keywords
A novel fluorescent endoplasmic reticulum marker for super‐resolution imaging in live cells
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14581
Abstract: Endoplasmic reticulum (ER) is a highly complicated and dynamic organelle that actively changes its shape and communicates with other organelles. Visualization of ER in live cells is of great importance to understand cellular activities. Here,… read more here.
Keywords: endoplasmic reticulum; marker super; super resolution; live cells ... See more keywords
T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12965
Abstract: Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration, but the underlying mechanisms remain largely unknown. We previously found that expression of TCC is… read more here.
Keywords: skeletal muscle; endoplasmic reticulum; muscle; c2c12 myotubes ... See more keywords
Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202039
Abstract: Pharmacological targeting of endoplasmic reticulum (ER) stress represents one of important methods for disease therapy, which, however, is significantly suppressed by the ER homeostatic processe. Herein, a proof‐of‐concept strategy is reported for persistent stimulation of… read more here.
Keywords: endoplasmic reticulum; peptide assemblies; cancer chemotherapy; stress ... See more keywords
An NIR-Fluorophore-Based Therapeutic Endoplasmic Reticulum Stress Inducer.
Sign Up to like & getrecommendations! Published in 2018 at "Advanced materials"
DOI: 10.1002/adma.201800475
Abstract: The endoplasmic reticulum (ER) stress signaling or unfolded protein response (UPR) is a common feature of many human diseases, including cancer. Excessive activation of ER stress directly induces cell death, holding a new promising strategy… read more here.
Keywords: endoplasmic reticulum; nir fluorophore; reticulum stress; stress ... See more keywords
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203831
Abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells… read more here.
Keywords: endoplasmic reticulum; antiviral innate; mediated antiviral; mavs ... See more keywords
Are endoplasmic reticulum subdomains shaped by asymmetric distribution of phospholipids? Evidence from a C. elegans model system
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000199
Abstract: Physical contact between organelles are widespread, in part to facilitate the shuttling of protein and lipid cargoes for cellular homeostasis. How do protein‐protein and protein‐lipid interactions shape organelle subdomains that constitute contact sites? The endoplasmic… read more here.
Keywords: protein; asymmetric distribution; reticulum subdomains; endoplasmic reticulum ... See more keywords
Structural basis of the conformational and functional regulation of human SERCA2b, the ubiquitous endoplasmic reticulum calcium pump
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DOI: 10.1002/bies.202200052
Abstract: Sarco/endoplasmic reticulum Ca2+ ATPase 2b (SERCA2b), a member of the SERCA family, is expressed ubiquitously and transports Ca2+ into the sarco/endoplasmic reticulum using the energy provided by ATP binding and hydrolysis. The crystal structure of… read more here.
Keywords: endoplasmic reticulum; functional regulation; structural basis; reticulum ... See more keywords
Angiotensin‐converting enzyme 2 inhibits endoplasmic reticulum stress–associated pathway to preserve nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3123
Abstract: Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin‐converting enzyme… read more here.
Keywords: fatty liver; endoplasmic reticulum; angiotensin converting; converting enzyme ... See more keywords