Illuminating the membrane contact sites between the endoplasmic reticulum and the trans‐Golgi network
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DOI: 10.1002/1873-3468.13639
Abstract: Membrane contact sites (MCSs) between different organelles have been identified and extensively studied over the last decade. Several classes of MCSs have now well‐established roles, although the contacts between the endoplasmic reticulum (ER) and the… read more here.
Keywords: membrane contact; endoplasmic reticulum; golgi network; contact sites ... See more keywords
The role of sphingolipids in endoplasmic reticulum stress
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DOI: 10.1002/1873-3468.13863
Abstract: The endoplasmic reticulum (ER) is an important intracellular compartment in eukaryotic cells and has diverse functions, including protein synthesis, protein folding, lipid metabolism and calcium homeostasis. ER functions are disrupted by various intracellular and extracellular… read more here.
Keywords: endoplasmic reticulum; role sphingolipids; reticulum stress; stress ... See more keywords
Diacylglycerol kinase alleviates autophagic degradation of the endoplasmic reticulum in SPT10‐deficient yeast to enhance triterpene biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14418
Abstract: A recent study showed that deletion of the gene encoding the transcription regulator SuPpressor of Ty10 (SPT10) increases total phospholipids, and our previous study established a critical link between phospholipids and the mevalonate/ergosterol (MEV/ERG) pathway,… read more here.
Keywords: endoplasmic reticulum; triterpene; spt10; spt10 yeast ... See more keywords
A novel fluorescent endoplasmic reticulum marker for super‐resolution imaging in live cells
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14581
Abstract: Endoplasmic reticulum (ER) is a highly complicated and dynamic organelle that actively changes its shape and communicates with other organelles. Visualization of ER in live cells is of great importance to understand cellular activities. Here,… read more here.
Keywords: endoplasmic reticulum; marker super; super resolution; live cells ... See more keywords
T‐type calcium channel blockade induces apoptosis in C2C12 myotubes and skeletal muscle via endoplasmic reticulum stress activation
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12965
Abstract: Loss of T‐type calcium channel (TCC) function has been reported to result in decreased cell viability and impaired muscle regeneration, but the underlying mechanisms remain largely unknown. We previously found that expression of TCC is… read more here.
Keywords: skeletal muscle; endoplasmic reticulum; muscle; c2c12 myotubes ... See more keywords
The effect of salubrinal on the endoplasmic reticulum stress pathway in heat-stressed spermatogonial cells in vitro.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS open bio"
DOI: 10.1002/2211-5463.70169
Abstract: In this study, we aimed to investigate the effect of salubrinal (SAL) on endoplasmic reticulum stress via an experimental in vitro heat stress model (HSM) of spermatogenic cells. In order to achieve this, mouse spermatogonium… read more here.
Keywords: sal; heat; stress; effect salubrinal ... See more keywords
Fluorogenic Probes for Functional Imaging of Endoplasmic Reticulum‐Resident Proteins: from Molecular Engineering to Biomedical Applications
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202416057
Abstract: Endoplasmic reticulum‐resident proteins (ERPs) are crucial for maintaining cellular homeostasis and are tightly associated with the onset and progression of various diseases. The emergence of fluorogenic probes responsive to ERPs has enabled scientists to in… read more here.
Keywords: resident proteins; biomedical applications; fluorogenic probes; engineering ... See more keywords
An Endoplasmic Reticulum‐Targeting and Calcium Metabolism‐Disrupting Nanodrug Enhances Tumor Photodynamic Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202424108
Abstract: The inefficient clearance of deep tumors and metastatic lesions greatly hinders the clinical applications of photodynamic therapy (PDT). Inducing robust immunogenic cell death (ICD) is crucial for improving PDT outcomes, as ICD‐mediated T‐cell adaptive immune… read more here.
Keywords: disrupting nanodrug; endoplasmic reticulum; photodynamic immunotherapy; calcium ... See more keywords
Piezo‐Electrons Induced Endoplasmic Reticulum Protein Misfolding to Enhance Immune Checkpoint Blockage Cancer Therapy
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DOI: 10.1002/adfm.202424874
Abstract: The endoplasmic reticulum (ER) is a crucial organelle in eukaryotic cells that regulates protein synthesis, folding, and transport, playing a vital role in maintaining protein homeostasis and functions. Tumor cells evade the immune surveillance and… read more here.
Keywords: cancer; reticulum; immune checkpoint; endoplasmic reticulum ... See more keywords
Supramolecular Self‐assembled Endoplasmic Reticulum‐Targeted Peptide Synergistically Triggers Type II ICD via Cascade Generation of Endogenous ROS and RNS for Cancer Immunotherapy
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DOI: 10.1002/adfm.202501271
Abstract: Endoplasmic reticulum (ER) stress triggered by reactive oxygen species (ROS) generated through photodynamic therapy emerges as an effective strategy for inducing immunogenic cell death (ICD). However, its therapeutic potential is often constrained by hypoxia and… read more here.
Keywords: generation; icd via; type icd; endoplasmic reticulum ... See more keywords
Modular Engineering of Enzyme‐Activatable DNA Nanodevices for Endoplasmic Reticulum‐Targeted Photodynamic Antitumor Therapy
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DOI: 10.1002/adfm.202503913
Abstract: Endoplasmic reticulum (ER)‐targeted photodynamic therapy (PDT) has garnered wide attention for its potential to improve tumor treatment outcomes. However, achieving spatially selective control over the activation of photosensitizers (PSs) within the ER remains a major… read more here.
Keywords: therapy; endoplasmic reticulum; enzyme activatable; reticulum targeted ... See more keywords