Structure-based drug designing towards the identification of potential anti-viral for COVID-19 by targeting endoribonuclease NSP15
Sign Up to like & getrecommendations! Published in 2020 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2020.100392
Abstract: Abstract The world is facing health and economic havoc due to the Corona Virus Disease-2019 (COVID-19) pandemic. Given the number of affected people and the mortality rate, the virus is undoubtedly a serious threat to… read more here.
Keywords: endoribonuclease nsp15; covid; structure based; based drug ... See more keywords
Identification of potential target endoribonuclease NSP15 inhibitors of SARS‐COV‐2 from natural products through high‐throughput virtual screening and molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Food Biochemistry"
DOI: 10.1111/jfbc.14085
Abstract: Abstract SARS‐CoV‐2 wreaks havoc around the world, triggering the COVID‐19 pandemic. It has been confirmed that the endoribonuclease NSP15 is crucial to the viral replication, and thus identified as a potential drug target against COVID‐19.… read more here.
Keywords: throughput virtual; natural products; virtual screening; high throughput ... See more keywords
Identification of Persuasive Antiviral Natural Compounds for COVID-19 by Targeting Endoribonuclease NSP15: A Structural-Bioinformatics Approach
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DOI: 10.3390/molecules25235657
Abstract: SARS-CoV-2 is a positive-stranded RNA virus that bundles its genomic material as messenger-sense RNA in infectious virions and replicates these genomes through RNA intermediates. Several virus-encoded nonstructural proteins play a key role during the viral… read more here.
Keywords: natural compounds; antiviral natural; identification persuasive; persuasive antiviral ... See more keywords