Endoscopic remission assessed with PICaSSO virtual electronic chromendoscopy accurately predicts clinical outcomes in ulcerative colitis.
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DOI: 10.1002/ueg2.12185
Abstract: BACKGROUND AND AIMS A composite endoscopic-histologic remission is increasingly explored as an important endpoint in ulcerative colitis (UC). We investigated combined endoscopic-histologic remission for predicting clinical outcomes at 12 months compared with endoscopic remission alone using… read more here.
Keywords: clinical outcomes; endoscopic remission; remission; histologic remission ... See more keywords
Endoscopy and histology in inflammatory bowel diseases patients: Complementary or alternatives?
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DOI: 10.1002/ueg2.12202
Abstract: To date, endoscopic remission is the main therapeutic target in patients with ulcerative colitis (UC), influencing treatment decisions. However, growing evidence shows that subjects with endoscopic remission but persistent histological activity have an increased risk… read more here.
Keywords: histology; endoscopic remission; score; disease ... See more keywords
Ratio of submucosal thickness to total bowel wall thickness as a new sonographic parameter to estimate endoscopic remission of ulcerative colitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-021-01847-3
Abstract: The development of feasible, reliable parameters and criteria for intestinal ultrasound (IUS) to estimate endoscopic remission of ulcerative colitis (UC) is a crucial clinical challenge. Such parameters must be simple, objective, and reproducible so that… read more here.
Keywords: parameter; estimate endoscopic; bowel wall; endoscopic remission ... See more keywords
Higher Mucosal Healing with Tumor Necrosis Factor Inhibitors in Combination with Thiopurines Compared to Methotrexate in Crohn’s Disease
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DOI: 10.1007/s10620-018-5422-8
Abstract: BackgroundThe differential impact of anti-tumor necrosis factor (anti-TNF) therapy with methotrexate versus thiopurine co-therapy on endoscopic remission remains uncertain.AimsTo compare rates of endoscopic remission based on methotrexate or thiopurine co-therapy used with anti-TNF therapy in… read more here.
Keywords: methotrexate; thiopurine; anti tnf; therapy ... See more keywords
Infliximab Trough Levels Are Not Predictive of Relapse in Patients with IBD in Endoscopic Remission: A Multicenter Cohort Study
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DOI: 10.1007/s10620-020-06645-0
Abstract: Therapeutic drug monitoring (TDM) is important in optimizing use of biologics in inflammatory bowel diseases (IBD). However, the role of proactive TDM during remission remains uncertain. This retrospective study included patients receiving infliximab (IFX) therapy… read more here.
Keywords: trough levels; remission; study; relapse ... See more keywords
DOP16 The ratio of submucosa thickness to the total bowel wall thickness can be a sonographic parameter to estimate endoscopic remission in Ulcerative Colitis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab073.055
Abstract: A less invasive examination that can estimate endoscopic remission is needed. Intestinal ultrasound (IUS) is a promising option. The bowel wall thickness (BWT) is a widely-accepted objective parameter in IUS to assess colonic inflammation, but… read more here.
Keywords: bwt; endoscopic remission; thickness; remission ... See more keywords
P246 Histologic remission is an important therapeutic target in patients who achieve endoscopic remission of ulcerative colitis
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DOI: 10.1093/ecco-jcc/jjad212.0376
Abstract: Histologic activity has been established as a crucial prognostic determinant in individuals diagnosed with ulcerative colitis(UC), while achieving histologic remission is increasingly recognized as a significant long-term therapeutic goal. However, the available literature still lacks… read more here.
Keywords: histologic remission; endoscopic remission; remission; ulcerative colitis ... See more keywords
P845 Vedolizumab induces endoscopic healing uniformly irrespective of disease location: post-hoc analysis of the LOVE-CD trial
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DOI: 10.1093/ecco-jcc/jjad212.0975
Abstract: Vedolizumab (VDZ) is a gut-selective anti–α4β7-integrin monoclonal antibody approved for the treatment of Crohn's disease (CD). We performed a post-hoc analysis of the LOVE-CD trial to evaluate the effect of disease location on endoscopic healing.… read more here.
Keywords: disease; itt nri; analysis; endoscopic remission ... See more keywords
P965 Ulcerative proctitis treated with biologics: is it too hard to treat?
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DOI: 10.1093/ecco-jcc/jjad212.1095
Abstract: Patients with ulcerative proctitis are widely considered a challenging population because the reported reduced response rate to conventional medical treatment. On the other hand, data on the role of biological therapies in this specific cohort… read more here.
Keywords: treated biologics; endoscopic remission; calprotectin; remission ... See more keywords
DOP005 Long-term efficacy and safety of mirikizumab treatment for Crohn’s Disease: Results from the VIVID-2 open-label extension study
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DOI: 10.1093/ecco-jcc/jjae190.0044
Abstract: VIVID-2 (NCT04232553) is an ongoing open-label long-term extension study of efficacy and safety of mirikizumab (MIRI), a selective interleukin-23p19 inhibitor, in patients with moderately to severely active Crohn’s disease (CD). We present efficacy and safety… read more here.
Keywords: safety; endoscopic remission; miri; vivid ... See more keywords
P0896 A double-blind, randomized, placebo-controlled, single-center, pilot study evaluating the efficacy of a synbiotic formulation in modulating gut microbiota biodiversity in patients with mild-to-moderate UC in clinical and endoscopic remission
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DOI: 10.1093/ecco-jcc/jjae190.1070
Abstract: Intestinal dysbiosis is considered a key factor in the pathogenesis and disease progression of Ulcerative Colitis (UC). Probiotics, prebiotics, and synbiotics are promising strategies for microbiota modulation and could play a role as "add-on" therapies… read more here.
Keywords: clinical endoscopic; gut microbiota; endoscopic remission; remission ... See more keywords