Analysis of Membrane Proteins Transport from Endosomal Compartments to Vacuoles.
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DOI: 10.1007/978-1-0716-0767-1_2
Abstract: Endocytosis and endosomal trafficking to vacuoles play important roles in regulating the homeostasis of plasma membrane (PM) proteins in plant cells. FREE1 (FYVE domain protein required for endosomal sorting 1) is a plant-unique component of… read more here.
Keywords: analysis membrane; membrane proteins; transport endosomal; endosomal compartments ... See more keywords
Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4.
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DOI: 10.1038/s41556-020-00596-4
Abstract: The canonical model of agonist-stimulated phosphatidylinositol-3-OH kinase (PI3K)-Akt signalling proposes that PI3K is activated at the plasma membrane, where receptors are activated and phosphatidylinositol-4,5-bisphosphate is concentrated. Here we show that phosphatidylinositol-3,4,5-trisphosphate generation and activated Akt… read more here.
Keywords: associated protein; microtubule; microtubule associated; kinase ... See more keywords
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
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DOI: 10.1038/s42003-022-03132-2
Abstract: The therapeutic and research potentials of oligonucleotides (ONs) have been hampered in part by their inability to effectively escape endosomal compartments to reach their cytosolic and nuclear targets. Splice-switching ONs (SSOs) can be used with… read more here.
Keywords: sso trafficking; delivery; novel endosomolytic; endosomolytic compounds ... See more keywords