MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways–Novel Insight into the Origins of Enamel Pathologies
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DOI: 10.1038/srep44118
Abstract: Amelogenesis imperfecta (AI) is group of inherited disorders resulting in enamel pathologies. The involvement of epigenetic regulation in the pathogenesis of AI is yet to be clarified due to a lack of knowledge about amelogenesis.… read more here.
Keywords: endocytotic endosomal; enamel pathologies; mir 153; amelogenesis targeting ... See more keywords
Neurodegeneration Upon Dysfunction of Endosomal/Lysosomal CLC Chloride Transporters
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DOI: 10.3389/fcell.2021.639231
Abstract: The regulation of luminal ion concentrations is critical for the function of, and transport between intracellular organelles. The importance of the acidic pH in the compartments of the endosomal-lysosomal pathway has been well-known for decades.… read more here.
Keywords: dysfunction; clc; ion; chloride ... See more keywords
Editorial: Signaling Proteins for Endosomal and Lysosomal Function
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DOI: 10.3389/fcell.2021.821719
Abstract: Protein Signaling Domains Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, United States, Medical Research Institute Mercedes and Martín Ferreyra (INIMEC-CONICET-UNC), Córdoba,… read more here.
Keywords: proteins endosomal; endosomal lysosomal; groningen; editorial signaling ... See more keywords
Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes
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DOI: 10.3390/ijms21145149
Abstract: Most common neurodegenerative diseases (NDs) are characterized by deposition of protein aggregates that are resulted from misfolding, dysregulated trafficking, and compromised proteolytic degradation. These proteins exert cellular toxicity to a broad range of brain cells… read more here.
Keywords: processing; associated proteins; lysosomal processing; neurodegeneration ... See more keywords