Interaction Kinetics of Individual mRNA-Containing Lipid Nanoparticles with an Endosomal Membrane Mimic: Dependence on pH, Protein Corona Formation, and Lipoprotein Depletion
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1021/acsnano.2c04829
Abstract: Lipid nanoparticles (LNPs) have emerged as potent carriers for mRNA delivery, but several challenges remain before this approach can offer broad clinical translation of mRNA therapeutics. To improve their efficacy, a better understanding is required… read more here.
Keywords: corona formation; endosomal membrane; membrane; protein corona ... See more keywords
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03132-2
Abstract: The therapeutic and research potentials of oligonucleotides (ONs) have been hampered in part by their inability to effectively escape endosomal compartments to reach their cytosolic and nuclear targets. Splice-switching ONs (SSOs) can be used with… read more here.
Keywords: sso trafficking; delivery; novel endosomolytic; endosomolytic compounds ... See more keywords
A SNX1–SNX2–VAPB partnership regulates endosomal membrane rewiring in response to nutritional stress
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201652
Abstract: A specific SNX1-dependent endosome tubulation towards autophagosome biogenesis-associated regions of the ER is generated by nutrient deprivation and regulated by the SNX2/VAPB tethering complex. Nutrient deprivation (“starvation”) is a major catabolic stress faced by mammalian… read more here.
Keywords: snx1; vapb; stress; nutritional stress ... See more keywords