Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration
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DOI: 10.1126/science.abq7860
Abstract: Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the C9orf72 gene and mutations in the TANK-binding kinase 1 (TBK1) gene. We found that TBK1 is phosphorylated in response… read more here.
Keywords: tdp pathology; endosomal pathway; pathology; pathway ... See more keywords