Manipulation of PD‐L1 Endosomal Trafficking Promotes Anticancer Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202206411
Abstract: The aberrant regulation of PD‐L1 in tumor cells remains poorly understood. Here, the authors systematically investigate the endosomal trafficking of plasma membrane PD‐L1 in tumor cells. They show that plasma membrane PD‐L1 is continuously internalized,… read more here.
Keywords: endosomal trafficking; tumor cells; manipulation endosomal; trafficking promotes ... See more keywords
Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.101942
Abstract: Sorafenib is a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), but its clinical effects are still limited. In this study we identify Quiescin sulfhydryl oxidase 1 (QSOX1) acting as a cellular pro-oxidant, specifically in… read more here.
Keywords: hepatocellular carcinoma; endosomal trafficking; sorafenib induced; sulfhydryl oxidase ... See more keywords
Vacuolin-1 inhibits endosomal trafficking and metastasis via CapZβ
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01662-3
Abstract: Metastasis is the fundamental cause of cancer mortality, but there are still very few anti-metastatic drugs available. Endosomal trafficking has been implicated in tumor metastasis, and we have previously found that small chemical vacuolin-1 (V1)… read more here.
Keywords: endosomal trafficking; trafficking metastasis; metastasis; capz ... See more keywords
Proteomics analysis identifies PEA-15 as an endosomal phosphoprotein that regulates α5β1 integrin endocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99348-z
Abstract: Endosomal trafficking of cell surface receptors is essential to their function. Integrins are transmembrane receptors that integrate adhesion to the extracellular matrix with engagement of the cytoskeleton. Ligated integrins mediate diverse signals that regulate matrix… read more here.
Keywords: endosomal trafficking; cell motility; phosphoprotein; pea ... See more keywords
Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.10.12.511914
Abstract: Potassium efflux via the two pore K+ channel TWIK2 is a requisite step for the activation of the NLRP3 inflammasome, however it is unclear how the efflux is activated in response to cues. Here we… read more here.
Keywords: twik2 plasmalemma; endosomal trafficking; inflammasome activation; activation ... See more keywords
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abm7134
Abstract: Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigger inflammasome formation and inflammatory… read more here.
Keywords: activation nlrp3; endosomal trafficking; endosome trafficking; traffic ... See more keywords
Participation of OCRL1, and APPL1, in the expression, proteolysis, phosphorylation and endosomal trafficking of megalin: Implications for Lowe Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.911664
Abstract: Megalin/LRP2 is the primary multiligand receptor for the re-absorption of low molecular weight proteins in the proximal renal tubule. Its function is significantly dependent on its endosomal trafficking. Megalin recycling from endosomal compartments is altered… read more here.
Keywords: megalin; endosomal trafficking; lowe syndrome; trafficking megalin ... See more keywords
PKAN hiPS-Derived Astrocytes Show Impairment of Endosomal Trafficking: A Potential Mechanism Underlying Iron Accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.878103
Abstract: PKAN disease is caused by mutations in the PANK2 gene, encoding the mitochondrial enzyme pantothenate kinase 2, catalyzing the first and key reaction in Coenzyme A (CoA) biosynthetic process. This disorder is characterized by progressive… read more here.
Keywords: derived astrocytes; hips derived; endosomal trafficking; iron ... See more keywords
VAPYRIN Marks an Endosomal Trafficking Compartment Involved in Arbuscular Mycorrhizal Symbiosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.00666
Abstract: Arbuscular mycorrhiza (AM) is a symbiosis between plants and AM fungi that requires the intracellular accommodation of the fungal partner in the host. For reciprocal nutrient exchange, AM fungi form intracellular arbuscules that are surrounded… read more here.
Keywords: endosomal trafficking; vapyrin marks; vapyrin; marks endosomal ... See more keywords