Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors
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DOI: 10.1016/j.nbd.2019.104632
Abstract: ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. To model ARFGEF1 haploinsufficiency observed in a recent Lennox Gastaut Syndrome patient, we studied a… read more here.
Keywords: arfgef1 haploinsufficiency; surface; endosome composition; gabaa receptors ... See more keywords