The Tetrahymena bcd1 mutant implicates endosome trafficking in ciliate, cortical pattern formation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-11-0501
Abstract: Ciliates, such as Tetrahymena thermophila, evolved complex mechanisms to determine both the location and dimensions of cortical organelles such as the oral apparatus (OA: involved in phagocytosis) cytoproct (Cyp: for eliminating wastes) and contractile vacuole… read more here.
Keywords: endosome trafficking; mutant; pka; tetrahymena bcd1 ... See more keywords
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abm7134
Abstract: Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and is regulated by subcellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigger inflammasome formation and inflammatory… read more here.
Keywords: activation nlrp3; endosomal trafficking; endosome trafficking; traffic ... See more keywords