Single-Molecule Sampling of Dihydrofolate Reductase Shows Kinetic Pauses and an Endosteric Effect Linked to Catalysis
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DOI: 10.1021/acscatal.1c04388
Abstract: The ability to sample multiple reactions on the same single enzyme is important to link rare intermediates with catalysis and to unravel the role of conformational changes. Despite decades of efforts, however, the single-molecule characterization… read more here.
Keywords: catalysis; dihydrofolate reductase; single molecule; endosteric effect ... See more keywords