Endothelial Activation and Stress Index (EASIX) Score at 100 Days Post-allo HCT in Patients with Acute Myeloid Leukemia Predicts Overall Survival
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.634
Abstract: Background Allogeneic hematopoietic stem cell transplant (HCT) is a potentially curative treatment modality for patients with AML. However, the success of transplant is limited by transplant-related mortality. Post-transplant complications have been linked to endothelial damage… read more here.
Keywords: allo hct; patients aml; hct; endothelial activation ... See more keywords
Low high-density lipoprotein cholesterol and particle concentrations are associated with greater levels of endothelial activation markers in Multi-Ethnic Study of Atherosclerosis participants.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of clinical lipidology"
DOI: 10.1016/j.jacl.2017.05.018
Abstract: BACKGROUND High-density lipoproteins (HDL) are well characterized for their role in reverse cholesterol transport but may confer other cardiovascular benefits-specifically, HDL may suppress the endothelial activation cascade in the initiating stages of atherogenesis. OBJECTIVE It… read more here.
Keywords: cholesterol; activation markers; density; activation ... See more keywords
Label-Free Multi Parameter Optical Interrogation of Endothelial Activation in Single Cells using a Lab on a Disc Platform
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40612-8
Abstract: Cellular activation and inflammation leading to endothelial dysfunction is associated with cardiovascular disease (CVD). We investigated whether a single cell label-free multi parameter optical interrogation system can detect endothelial cell and endothelial progenitor cell (EPC)… read more here.
Keywords: multi parameter; free multi; label free; activation ... See more keywords
Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria
Sign Up to like & getrecommendations! Published in 2020 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000004469
Abstract: Supplemental Digital Content is available in the text. Objectives: Evaluate the relationship between endothelial activation, malaria complications, and long-term cognitive outcomes in severe malaria survivors. Design: Prospectively cohort study of children with cerebral malaria, severe… read more here.
Keywords: kidney injury; endothelial activation; severe malaria; acute kidney ... See more keywords
R-spondin 3 Inhibits High Glucose-Induced Endothelial Activation Through Leucine-Rich G Protein-Coupled Receptor 4/Wnt/β-catenin Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001295
Abstract: Abstract: High glucose-induced endothelial activation plays critical roles in the development of diabetic vascular complications. R-spondin 3 could inhibit inflammatory damage, and diabetic vascular inflammation is secondary to endothelial activation. In this article, we identify… read more here.
Keywords: glucose induced; spondin; high glucose; endothelial activation ... See more keywords
Endothelial activation predicts disseminated intravascular coagulopathy, cytokine release syndrome and prognosis in patients treated with anti‐CD19 CAR‐T cells
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18596
Abstract: Cytokine release syndrome (CRS) and consumptive coagulopathy can complicate the treatment with chimeric antigen receptor T (CAR‐T) cells. The modified version of the Endothelial Activation and Stress Index (mEASIX), a score derived from haematopoietic stem… read more here.
Keywords: release syndrome; anti cd19; car; car cells ... See more keywords
Endothelial activation is associated with intestinal epithelial injury, systemic inflammation and treatment regimen in children living with vertically acquired HIV‐1 infection
Sign Up to like & getrecommendations! Published in 2020 at "HIV Medicine"
DOI: 10.1111/hiv.13012
Abstract: Premature development of cardiovascular disease in children living with HIV‐1 (CLWH) may be associated with compromised gut barrier function, microbial translocation, immune activation, systemic inflammation and endothelial activation. Biomarkers of these pathways may provide insights… read more here.
Keywords: children living; activation; endothelial activation; systemic inflammation ... See more keywords
Arterial structure and function in Africans with HIV for > 5 years: longitudinal relationship with endothelial activation and cardiovascular risk markers
Sign Up to like & getrecommendations! Published in 2021 at "HIV Medicine"
DOI: 10.1111/hiv.13111
Abstract: We aimed to determine whether people with human immunodeficiency virus (PWHIV) have increased measures of arterial injury [carotid intima‐media thickness (cIMT)] and large artery stiffness [carotid‐femoral pulse wave velocity (cfPWV)] when compared with their counterparts… read more here.
Keywords: endothelial activation; activation cardiovascular; cardiovascular risk;
Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection
Sign Up to like & getrecommendations! Published in 2020 at "Infection and Immunity"
DOI: 10.1128/iai.00895-19
Abstract: Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced Plasmodium falciparum and P. vivax infection. Participants were enrolled in induced blood-stage… read more here.
Keywords: plasmodium; activation; falciparum; endothelial activation ... See more keywords
Direct Activation of Endothelial Cells by SARS-CoV-2 Nucleocapsid Protein Is Blocked by Simvastatin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.01396-21
Abstract: Coronavirus disease 2019 (COVID-19), caused by the betacoronavirus SARS-CoV-2, is a worldwide challenge for health care systems. The leading cause of mortality in patients with COVID-19 is hypoxic respiratory failure from acute respiratory distress syndrome… read more here.
Keywords: endothelial activation; nucleocapsid protein; sars cov; covid ... See more keywords
Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.01325-22
Abstract: In children with severe malaria, intestinal injury is a common complication associated with increased mortality. Intestinal injury is associated with acute kidney injury, acidosis, and endothelial activation. Interventions promoting intestinal regeneration and repair represent novel… read more here.
Keywords: severe malaria; mortality; malaria intestinal; injury ... See more keywords