Use of Elastic, Porous, and Ultrathin Co‐Culture Membranes to Control the Endothelial Barrier Function via Cell Alignment
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202008172
Abstract: Porous membranes used in co‐culture enable the in vitro partitioning of cellular microenvironments, while still permitting physical and biochemical crosstalk between cells. Thus, features of the co‐culture membrane are crucial for recapitulating the physiological functions… read more here.
Keywords: culture; barrier function; endothelial barrier; cell alignment ... See more keywords
Measurement of Endothelial Barrier Function in Mouse Models of Cerebral Cavernous Malformations Using Intravital Microscopy.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0640-7_28
Abstract: Vascular permeability is a major function of the microvasculature that is regulated by multiple factors including blood pressure, blood viscosity, and endothelial barrier function. Intravital microscopy has been used to directly assess vascular permeability in… read more here.
Keywords: microscopy; intravital microscopy; endothelial barrier; barrier function ... See more keywords
A Novel Microscopic Assay Reveals Heterogeneous Regulation of Local Endothelial Barrier Function.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.02.008
Abstract: Blood vessels are covered with endothelial cells on their inner surfaces, forming a selective and semipermeable barrier between the blood and the underlying tissue. Many pathological processes, such as inflammation or cancer metastasis, are accompanied… read more here.
Keywords: barrier; endothelial barrier; permeability; barrier function ... See more keywords
Restoring the endothelial barrier function in the elderly
Sign Up to like & getrecommendations! Published in 2021 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2021.111479
Abstract: Endothelial barrier dysfunction in the elderly has been associated with severe disorders, including acute respiratory distress syndrome, sepsis and COVID-19. Here in we deliver an opinion regarding the development of alternative therapeutic avenues to counteract… read more here.
Keywords: barrier; endothelial barrier; restoring endothelial; function elderly ... See more keywords
Permeability of the Endothelial Barrier: Identifying and Reconciling Controversies.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2020.11.006
Abstract: Leakage from blood vessels into tissues is governed by mechanisms that control endothelial barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes to many conditions and can influence disease morbidity and treatment. Diverse approaches used… read more here.
Keywords: barrier; endothelial barrier; identifying reconciling; reconciling controversies ... See more keywords
Tumor necrosis factor-α requires Ezrin to regulate the cytoskeleton and cause pulmonary microvascular endothelial barrier damage
Sign Up to like & getrecommendations! Published in 2020 at "Microvascular Research"
DOI: 10.1016/j.mvr.2020.104093
Abstract: Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease with unknown pathogenesis. Damage of pulmonary microvascular endothelial cells(PMVECs) caused by inflammatory storm caused by cytokines such as TNF- α is the potential pathogenesis of… read more here.
Keywords: cytoskeleton; barrier; endothelial barrier; microvascular endothelial ... See more keywords
Placental hypoxia-induced alterations in vascular function, morphology, and endothelial barrier integrity
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension Research"
DOI: 10.1038/s41440-020-0528-8
Abstract: Preeclampsia (PE) is a pregnancy-related disorder characterized by hypertension and proteinuria that affects 3–10% of all pregnancies. Although its pathophysiology remains obscure, placental hypoxia-induced oxidative stress and alterations in vascular function, morphology, and endothelial barrier… read more here.
Keywords: hypoxia; barrier integrity; morphology; endothelial barrier ... See more keywords
A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10392-0
Abstract: Endothelial barrier function is carefully controlled to protect tissues from edema and damage inflicted by extravasated leukocytes. RhoGTPases, in conjunction with myriad regulatory proteins, exert both positive and negative effects on the endothelial barrier integrity.… read more here.
Keywords: cdc42; barrier; endothelial barrier; integrity ... See more keywords
Histamine causes endothelial barrier disruption via Ca2+-mediated RhoA activation and tension at adherens junctions
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31408-3
Abstract: During inflammation, the disruption of the endothelial barrier leads to increased microvascular permeability. Whether tension along cell junctions contributes to histamine-induced endothelial barrier disruption remains unknown. Rapid Ca2+ influx induced by both histamine and thrombin… read more here.
Keywords: barrier; disruption; endothelial barrier; ca2 ... See more keywords
Impairment of lymphatic endothelial barrier function by X-ray irradiation
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2019.1562253
Abstract: Abstract Purpose: Although the microvascular system is a significant target for radiation-induced effects, the lymphatic response to radiation has not been extensively investigated. This is one of the first investigations characterizing the lymphatic endothelial response… read more here.
Keywords: irradiation; response; endothelial barrier; lymphatic endothelial ... See more keywords
Characterization of cell-cell junction changes associated with the formation of a strong endothelial barrier
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Barriers"
DOI: 10.1080/21688370.2017.1405774
Abstract: ABSTRACT A principal function of endothelial cells is the formation of a barrier between the blood and tissues. This barrier arises from the physical connections at cell-cell junctions, which includes cytoskeletal tight junction and adherens… read more here.
Keywords: cell; endothelial barrier; junction; function ... See more keywords