Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12504
Abstract: The tumor microenvironment contains various components, including cancer cells, tumor vessels, and cancer‐associated fibroblasts, the latter of which are comprised of tumor‐promoting myofibroblasts and tumor‐suppressing fibroblasts. Multiple lines of evidence indicate that transforming growth factor‐β… read more here.
Keywords: growth factor; tgf; endothelial cells; growth ... See more keywords
Overexpression of interleukin‐10 in engineered macrophages protects endothelial cells against LPS‐induced injury in vitro
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13365
Abstract: Endothelial dysfunction is a primary pathophysiological change in sepsis. Macrophages are known to interact with vascular endothelial cells during the development of sepsis. Recently, drug delivery based on engineered macrophages was reported as an alternative… read more here.
Keywords: engineered macrophages; endothelial cells; lps induced; cells lps ... See more keywords
HSP70 governs permeability and mechanotransduction in primary human endothelial cells.
Sign Up to like & getrecommendations! Published in 2025 at "FEBS open bio"
DOI: 10.1002/2211-5463.70129
Abstract: Vascular barrier disruption is a hallmark of diseases such as cardiovascular disease, stroke, hypertension, pulmonary disorders, infections, and cancer. Endothelium permeability is tightly regulated by shear stress, allowing tissue perfusion, while disturbed flow leads to… read more here.
Keywords: permeability; hsp70; cell; hsp70 governs ... See more keywords
Matrix‐Embedded Endothelial Cells Attain a Progenitor‐Like Phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700057
Abstract: Culture of endothelial cells (ECs) embedded in 3D scaffolds of denatured collagen has shown tremendous therapeutic potential in clinical trials of tissue repair. It is postulated that these matrix‐embedded ECs (MEECs) attain a differential phenotype… read more here.
Keywords: phenotype; matrix embedded; expression; endothelial cells ... See more keywords
Delivery of Anti-microRNA-712 to Inflamed Endothelial Cells Using Poly(β-amino ester) Nanoparticles Conjugated with VCAM-1 Targeting Peptide.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001894
Abstract: Endothelial cells (ECs) are an important target for therapy in a wide range of diseases, most notably atherosclerosis. Developing efficient nanoparticle (NP) systems that deliver RNA interference (RNAi) drugs specifically to dysfunctional ECs in vivo… read more here.
Keywords: mir 712; anti microrna; endothelial cells; amino ester ... See more keywords
Verification of therapeutic effect through Accelerator Mass Spectrometry based single cell level quantification of hESC-endothelial cells distributed into an ischemic model.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300476
Abstract: As the potential of pluripotent stem cell-derived differentiated cells has been demonstrated in regenerative medicine, differentiated vascular endothelial cells (ECs) are emerging as a therapeutic agent for the cardiovascular system. To verify the therapeutic efficacy… read more here.
Keywords: cell; quantification; ischemic model; endothelial cells ... See more keywords
Biofabrication of a Filtration Barrier by Integrating Electrospun Membranes and Flow in a Glomerular Co‐Culture
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501235
Abstract: The glomerular filtration barrier (GFB), composed of glomerular endothelial cells, podocytes, and the glomerular basement membrane (GBM), is essential for selective filtration in the kidney. Damage to any GFB component results in proteinuria and kidney… read more here.
Keywords: filtration barrier; filtration; culture; cell ... See more keywords
Primary Human Breast Cancer‐Associated Endothelial Cells Favor Interactions with Nanomedicines
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202403986
Abstract: Cancer nanomedicines predominately rely on transport processes controlled by tumor‐associated endothelial cells to deliver therapeutic and diagnostic payloads into solid tumors. While the dominant role of this class of endothelial cells for nanoparticle transport and… read more here.
Keywords: cancer; primary human; tumor; human breast ... See more keywords
Endothelial Retargeting of AAV9 In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103867
Abstract: Adeno‐associated viruses (AAVs) are frequently used for gene transfer and gene editing in vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV‐transduction. AAVs are retargeted here toward endothelial cells by coating with… read more here.
Keywords: endothelial cells; endothelial retargeting; g2cnn aav9; mice ... See more keywords
Scar‐Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203315
Abstract: Deposition of extracellular matrix (ECM) in the liver is an important feature of liver cirrhosis. Recovery from liver cirrhosis is physiologically challenging, partially due to the ECM in scar tissue showing resistance to cell‐mediated degradation… read more here.
Keywords: liver fibrosis; endothelial cells; degrading endothelial; advanced liver ... See more keywords
Comment on "Scar-Degrading Endothelial Cells as a Treatment for Advanced Liver Fibrosis".
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202207396
Abstract: Cellular therapies show promise for treatment of fibrosis. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. A discussion is presented surrounding the strengths of this… read more here.
Keywords: scar degrading; endothelial cells; comment scar; treatment ... See more keywords