Endothelial Glycocalyx.
Sign Up to like & getrecommendations! Published in 2022 at "Comprehensive Physiology"
DOI: 10.1002/cphy.c210029
Abstract: The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is primarily conformed of glycoproteins and proteoglycans, which provide communication, electrostatic charge, ionic buffering, permeability, and mechanosensation-mechanotransduction capabilities to cells.… read more here.
Keywords: physiology; blood; degradation; glycocalyx ... See more keywords
Association of COVID‐19 with impaired endothelial glycocalyx, vascular function and myocardial deformation four months after infection
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2326
Abstract: Abstract Aims SARS‐CoV‐2 infection may lead to endothelial and vascular dysfunction. We investigated alterations of arterial stiffness, endothelial coronary and myocardial function markers four months after COVID‐19 infection. Methods and Results In a case‐control prospective… read more here.
Keywords: infection; months infection; endothelial glycocalyx; function ... See more keywords
Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-022-01854-w
Abstract: In this study, the effect of heterozygous germline mutations in the heparan sulfate (HS) glycosaminoglycan chain co-polymerases EXT1 and EXT2 on glomerular barrier function and the endothelial glycocalyx in humans is investigated. Heparan sulfate (HS)… read more here.
Keywords: glycocalyx; heparan sulfate; ext1 ext2; endothelial glycocalyx ... See more keywords
Dexmedetomidine preserves the endothelial glycocalyx and improves survival in a rat heatstroke model
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DOI: 10.1007/s00540-018-2568-7
Abstract: PurposeHeatstroke causes systemic inflammation, followed by vascular endothelial damage. The normal vascular endothelium is coated by endothelial glycocalyx (EGCX). Dexmedetomidine (DEX) has an anti-inflammatory effect, but there has been little investigation on the influence of… read more here.
Keywords: heat exposure; endothelial glycocalyx; group; dex ... See more keywords
Endothelial glycocalyx breakdown is mediated by angiopoietin-2
Sign Up to like & getrecommendations! Published in 2017 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvx023
Abstract: Aims The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage and adhesion in sepsis and vessel inflammation. Angiopoietin-2 (Angpt-2), an antagonist of… read more here.
Keywords: glycocalyx breakdown; mediated angiopoietin; endothelial glycocalyx; breakdown mediated ... See more keywords
The predictive role of endothelial glycocalyx in primary prevention of cardiovascular events:a 6 year follow-up study
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3780
Abstract: Endothelial glycocalyx is a layer of glycoproteins on endothelial cells preventing vascular wall permeability to circulating proteins and blood cells. Perfused Boundary Region (PBR) of arterial microvessel is a non-invasive marker of endothelial glycocalyx thickness,… read more here.
Keywords: risk; glycocalyx; pbr; endothelial glycocalyx ... See more keywords
Endothelial glycocalyx—the battleground for complications of sepsis and kidney injury
Sign Up to like & getrecommendations! Published in 2018 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfx076
Abstract: After briefly discussing endothelial glycocalyx and its role in vascular physiology and renal disease, this overview focuses on its degradation very early in the course of microbial sepsis. We describe our recently proposed mechanism for… read more here.
Keywords: glycocalyx; glycocalyx battleground; battleground complications; sepsis kidney ... See more keywords
The endothelial glycocalyx and perioperative lung injury
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Anaesthesiology"
DOI: 10.1097/aco.0000000000000434
Abstract: Purpose of review Ventilator-induced lung injury is a major contributor to perioperative lung injury. The end-expiratory lung volume, regional lung overdistension, and tidal recruitment are known to be the main factors causing subsequent alveolar damage… read more here.
Keywords: perioperative lung; endothelial glycocalyx; injury; lung injury ... See more keywords
ENDOTHELIAL GLYCOCALYX SHEDDING PREDICTS DONOR ORGAN ACCEPTABILITY AND IS ASSOCIATED WITH PRIMARY GRAFT DYSFUNCTION IN LUNG TRANSPLANT RECIPIENTS.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/tp.0000000000002539
Abstract: BACKGROUND The endothelial glycocalyx, a sieve-like structure located on the luminal surface of all blood vessels, has been found to be integral to regulation of capillary permeability and mechanotransduction. Given this, we investigated the role… read more here.
Keywords: lung; endothelial glycocalyx; transplant; organ acceptability ... See more keywords
Hypervolemia does not cause degradation of the endothelial glycocalyx layer during open hysterectomy performed under sevoflurane or propofol anesthesia
Sign Up to like & getrecommendations! Published in 2019 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.13511
Abstract: Fluid‐induced hypervolemia may stimulate the release of natriuretic peptides and cause degradation (shedding) of the endothelial glycocalyx layer. Sevoflurane is believed to protect the glycocalyx, but the importance of using sevoflurane to prevent shedding during… read more here.
Keywords: cause degradation; glycocalyx; glycocalyx layer; endothelial glycocalyx ... See more keywords
Plasma syndecan-1 concentration as a biomarker for endothelial glycocalyx degradation in septic adult horses.
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DOI: 10.1111/evj.13862
Abstract: BACKGROUND Limited information is available regarding endothelial glycocalyx degradation during sepsis in horses. Plasma syndecan-1 concentrations are increased in consequence to sepsis in other species and have been useful for prognostication. OBJECTIVES To determine whether… read more here.
Keywords: sepsis; group; plasma syndecan; adult horses ... See more keywords