New [1,2,4]triazolo[4,3‐c]quinazoline derivatives as vascular endothelial growth factor receptor‐2 inhibitors and apoptosis inducers: Design, synthesis, docking, and antiproliferative evaluation
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DOI: 10.1002/ardp.202200133
Abstract: In continuation of our previous efforts in the field of design and synthesis of vascular endothelial growth factor receptor (VEGFR)‐2 inhibitors, a new series of [1,2,4]triazolo[4,3‐c]quinazoline derivatives were designed and synthesized as modified analogs of… read more here.
Keywords: design synthesis; compound; endothelial growth; factor receptor ... See more keywords
Early hypertension and neutropenia are predictors of treatment efficacy in metastatic colorectal cancer patients administered FOLFIRI and vascular endothelial growth factor inhibitors as second‐line chemotherapy
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DOI: 10.1002/cam4.3638
Abstract: Three vascular endothelial growth factor (VEGF) inhibitors, Bevacizumab (BEV), ramucirumab (RAM), and aflibercept (AFL), are widely used for metastatic colorectal cancer (mCRC) patients who are treated with second‐line chemotherapy. The difference in outcome between the… read more here.
Keywords: vascular endothelial; endothelial growth; growth factor; cancer ... See more keywords
Vascular endothelial growth factor and programmed death‐1 pathway inhibitors in renal cell carcinoma
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DOI: 10.1002/cncr.32361
Abstract: Advanced renal cell carcinoma has historically carried a poor prognosis with very limited treatment options. However, in recent years, the treatment landscape has changed drastically, with many new therapeutic options and improved survival for patients.… read more here.
Keywords: renal cell; vascular endothelial; endothelial growth; cell carcinoma ... See more keywords
The potential role of vascular endothelial growth factor as a new biomarker in severe intracerebral hemorrhage
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DOI: 10.1002/jcla.22076
Abstract: We studied the association between high serum levels of vascular endothelial growth factor (VEGF) and clinical outcomes of intracerebral hemorrhage (ICH) patients. read more here.
Keywords: growth factor; endothelial growth; intracerebral hemorrhage; vascular endothelial ... See more keywords
Haplotype‐based association of Vascular Endothelial Growth Factor gene polymorphisms with urothelial bladder cancer risk in Tunisian population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22610
Abstract: Accumulated data suggested that Vascular Endothelial Growth Factor is a major mediator in vasculogenesis, angiogenesis and recently in tumorigenesis. Therefore, we aimed to investigate for the first time the association between VEGF gene variants (‐2549I/D… read more here.
Keywords: bladder cancer; tunisian population; urothelial bladder; vascular endothelial ... See more keywords
Retinal pigment epithelium‐derived transforming growth factor‐β2 inhibits the angiogenic response of endothelial cells by decreasing vascular endothelial growth factor receptor‐2 expression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27156
Abstract: Transforming growth factor‐β (TGF‐β) is a multifunctional cytokine that is known to modulate various aspects of endothelial cell (EC) biology. Retinal pigment epithelium (RPE) is important for regulating angiogenesis of choriocapillaris and one of the… read more here.
Keywords: vascular endothelial; endothelial growth; growth factor; expression ... See more keywords
Conformational latitude – activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin‐1
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DOI: 10.1002/psc.3009
Abstract: Neuropilin‐1 (NRP‐1) has been found to be overexpressed in several kinds of malignant tumors, and it is postulated that in pathological angiogenesis, its interaction with the vascular endothelial growth factor 165 (VEGF165) leads to progression… read more here.
Keywords: vascular endothelial; endothelial growth; activity; growth factor ... See more keywords
Evaluation of a xenogeneic vascular endothelial growth factor-2 vaccine in two preclinical metastatic tumor models in mice
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DOI: 10.1007/s00262-017-2046-3
Abstract: In this study, a xenogeneic DNA vaccine encoding for human vascular endothelial growth factor receptor-2 (hVEGFR-2) was evaluated in two murine tumor models, the B16-F10 melanoma and the EO771 breast carcinoma model. The vaccine was… read more here.
Keywords: vascular endothelial; endothelial growth; growth factor; vaccine ... See more keywords
Mathematical models for the effect of anti-vascular endothelial growth factor on visual acuity.
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DOI: 10.1007/s00285-020-01544-4
Abstract: The standard of care treatment for neovascular age-related macular degeneration, delivered as ocular injection, is based on anti-vascular endothelial growth factor (anti-VEGF). The course of treatment may need to be modified quickly for certain patients… read more here.
Keywords: growth factor; endothelial growth; anti vascular; vascular endothelial ... See more keywords
Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling
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DOI: 10.1007/s10456-018-9606-9
Abstract: AbstractVascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2–3 form the ligand-binding… read more here.
Keywords: vascular endothelial; endothelial growth; growth factor; site ... See more keywords
The efficacy of different anti-vascular endothelial growth factor agents and prognostic biomarkers in monitoring of the treatment for myopic choroidal neovascularization
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DOI: 10.1007/s10792-022-02261-1
Abstract: To evaluate anatomical and visual results of eyes with naive myopic choroidal neovascularization (mCNV) in patients treated with intravitreal anti-vascular endothelial growth factor (VEGF) therapies. This is a retrospective, non-randomized, comperative, intervetional study. One hundred… read more here.
Keywords: ivr; vascular endothelial; myopic choroidal; choroidal neovascularization ... See more keywords