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   Articles with "endothelial hematopoietic" as a keyword



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Single-Cell Analysis Identifies Distinct Stages of Human Endothelial-to-Hematopoietic Transition.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.03.023

Abstract: During development, hematopoietic cells originate from endothelium in a process known as endothelial-to-hematopoietic transition (EHT). To study human EHT, we coupled flow cytometry and single-cell transcriptional analyses of human pluripotent stem cell-derived CD34+ cells. The… read more here.

Keywords: single cell; endothelial hematopoietic; hematopoietic transition; cell ... See more keywords
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3098 – THE ROLE OF GATA2 IN HSC GENERATION THROUGH ENDOTHELIAL-TO-HEMATOPOIETIC TRANSITION

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recommendations! Published in 2020 at "Experimental Hematology"

DOI: 10.1016/j.exphem.2020.09.111

Abstract: GATA2 is the most frequently mutated gene in childhood AML. These patients have germline mutations in one allele of GATA2 and have a high predisposition for MDS/AML. Also, in mouse, Gata2 is required for embryonic… read more here.

Keywords: endothelial hematopoietic; gata2 haploinsufficiency; hsc generation; gata2 ... See more keywords
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HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition

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recommendations! Published in 2018 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2018.03.011

Abstract: Summary The first hematopoietic stem and progenitor cells are generated during development from hemogenic endothelium (HE) through trans-differentiation. The molecular mechanisms underlying this endothelial-to-hematopoietic transition (EHT) remain poorly understood. Here, we explored the role of… read more here.

Keywords: hdac1 hdac2; tgf signaling; endothelial hematopoietic; hematopoietic transition ... See more keywords
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Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic vs. hepatic actions of semaglutide.

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recommendations! Published in 2021 at "JCI insight"

DOI: 10.1172/jci.insight.153732

Abstract: Glucagon-like peptide-1 receptor agonists (GLP-1RA) are used to treat diabetes and obesity and reduce rates of major cardiovascular events such as stroke and myocardial infarction. Nevertheless, the identity of GLP-1R-expressing cell types mediating the cardiovascular… read more here.

Keywords: glp 1ra; endothelial hematopoietic; glp1rtie2 mice; hematopoietic cell ... See more keywords