6‐Hydroxydopamine induces brain vascular endothelial inflammation
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1685
Abstract: Disruption of the blood‐brain barrier associated with endothelial dysfunction is an important hallmark of Parkinson's disease (PD). 6‐Hydroxydopamine (6‐OHDA) is a synthetic dopamine derivate often used to model PD as it results in retrograde degeneration… read more here.
Keywords: endothelial inflammation; brain; endothelial dysfunction; hydroxydopamine induces ... See more keywords
Dynamic alterations of H3K4me3 and H3K27me3 at ADAM17 and Jagged-1 gene promoters cause an inflammatory switch of endothelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30579
Abstract: Histone protein modifications control the inflammatory state of many immune cells. However, how dynamic alteration in histone methylation causes endothelial inflammation and apoptosis is not clearly understood. To examine this, we explored two contrasting histone… read more here.
Keywords: gene promoters; adam17 jagged; inflammation; endothelial inflammation ... See more keywords
NINJ2- A novel regulator of endothelial inflammation and activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.04.011
Abstract: Previous genetic studies suggested that variants in NINJ2 (encode ninjurin2) confer risk to ischemic stroke or large artery atherosclerotic stroke. However, the underlying mechanisms of NINJ2 in ischemic stroke or atherosclerosis are still unknown. In… read more here.
Keywords: inflammation activation; novel regulator; inflammation; endothelial inflammation ... See more keywords
c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy.
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DOI: 10.1016/j.cellsig.2022.110263
Abstract: Diabetic nephropathy (DN) is a common vascular complication of diabetes. Endothelial adhesion molecules are involved in physiopathology of DN. Interleukin-1 receptor-associated kinase 1 (IRAK1) and c-Myc participate in inflammation in DN. We hypothesized c-Myc modulates… read more here.
Keywords: expression; endothelial inflammation; high glucose; inflammation ... See more keywords
Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115158118
Abstract: Vascular endothelial cells are exposed to shear stresses with disturbed vs. laminar flow patterns, which lead to proinflammatory vs. antiinflammatory phenotypes, respectively. Effective treatment against endothelial inflammation and the consequent atherogenesis requires the identification of… read more here.
Keywords: induced endothelial; endothelial inflammation; vitexin; flow induced ... See more keywords
MO396NOVEL ENDOTHELIAL INFLAMMATION BIOMARKERS IN SNAKEBITES-ASSOCIATED ACUTE KIDNEY INJURY
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DOI: 10.1093/ndt/gfab082.0050
Abstract: Acute kidney injury (AKI) is a frequent and potentially fatal complications of snakebites. Coagulation disturbances are observed and have a high probability to be involved in AKI pathogenesis. Novel endothelial inflammation biomarkers are capable of… read more here.
Keywords: endothelial inflammation; kidney injury; inflammation biomarkers; acute kidney ... See more keywords
MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis
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DOI: 10.1155/2020/8864322
Abstract: Background The endothelium is the first line of defence against harmful microenvironment risks, and microRNAs (miRNAs) involved in vascular inflammation may be promising therapeutic targets to modulate atherosclerosis progression. In this study, we aimed to… read more here.
Keywords: microrna 216a; mir 216a; inflammation; endothelial inflammation ... See more keywords
Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.123.319026
Abstract: Background: Insufficient or disrupted sleep increases the risk of cardiovascular disease, including atherosclerosis. However, we know little about the molecular mechanisms by which sleep modulates atherogenesis. This study aimed to explore the potential role of… read more here.
Keywords: endothelial inflammation; inflammation atherogenesis; sleep deprivation; deprivation ... See more keywords
NDRG1 Signaling Is Essential for Endothelial Inflammation and Vascular Remodeling
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DOI: 10.1161/circresaha.122.321837
Abstract: Background: NDRG-1 (N-myc downstream-regulated gene 1) is a member of NDRG family that plays essential roles in cell differentiation, proliferation, and stress responses. Although the expression of NDRG1 is regulated by fluid shear stress, its… read more here.
Keywords: inflammation; endothelial inflammation; endothelial cells; expression ... See more keywords
Severe vitamin D deficiency is associated with endothelial inflammation in healthy individuals even in the absence of subclinical atherosclerosis.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202210_29888
Abstract: OBJECTIVE Vitamin D has beneficial effects, some of which involve the cardiovascular system. No study to date has investigated the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels… read more here.
Keywords: absence subclinical; endothelial inflammation; serum; vitamin ... See more keywords
Edgeworthia gardneri (Wall.) Meisn. extract protects against myocardial infarction by inhibiting NF-κB-and MAPK-mediated endothelial inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.1013013
Abstract: Background Experimental and clinical evidence has demonstrated a pivotal role of inflammation in the pathogenesis of ischemic heart disease, and targeting inflammation has been shown to provide clinical benefits for patients with coronary disease. Endothelial… read more here.
Keywords: inflammation; endothelial inflammation; edgeworthia gardneri; gardneri wall ... See more keywords