Neuraminidase causes endothelial phosphatidylserine externalization and ADAM17 activation: implications for shedding of insulin receptor and endothelial insulin resistance
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732976
Abstract: Endothelial insulin resistance represents a causal factor in the pathogenesis of type 2 diabetes (T2D) and vascular disease, thus underscoring the need to identify molecular mechanisms underlying defects in endothelial insulin signaling. We previously showed… read more here.
Keywords: insulin resistance; externalization; physiology; endothelial insulin ... See more keywords
Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2018-00215
Abstract: Abstract Reduced systemic insulin signaling promotes endothelial dysfunction and diminished endogenous vascular repair. We investigated whether restoration of endothelial insulin receptor expression could rescue this phenotype. Insulin receptor knockout (IRKO) mice were crossed with mice… read more here.
Keywords: insulin; endothelial insulin; hireco; insulin receptor ... See more keywords