Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.07.012
Abstract: Summary The migration of neutrophils from the blood circulation to sites of infection or injury is a key immune response and requires the breaching of endothelial cells (ECs) that line the inner aspect of blood… read more here.
Keywords: endothelial junctions; autophagy modulates; inflammation; modulates endothelial ... See more keywords
VE-PTP inhibition stabilizes endothelial junctions by activating FGD5.
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201847046
Abstract: Inhibition of VE-PTP, an endothelial receptor-type tyrosine phosphatase, triggers phosphorylation of the tyrosine kinase receptor Tie-2, which leads to the suppression of inflammation-induced vascular permeability. Analyzing the underlying mechanism, we show here that inhibition of… read more here.
Keywords: ptp inhibition; endothelial junctions; inhibition; fgd5 ... See more keywords
Mechanisms Ensuring Endothelial Junction Integrity Beyond VE-Cadherin
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00519
Abstract: Endothelial junctions provide blood and lymph vessel integrity and are essential for the formation of a vascular system. They control the extravasation of solutes, leukocytes and metastatic cells from blood vessels and the uptake of… read more here.
Keywords: endothelial junctions; vascular system; integrity; junction ... See more keywords