Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Lipid Research"
DOI: 10.1016/j.jlr.2021.100112
Abstract: High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3… read more here.
Keywords: angptl3; inhibition; endothelial lipase; hdl ... See more keywords
Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00424
Abstract: Endothelial lipase (EL) selectively metabolizes high density lipoprotein (HDL) particles. Inhibition of EL has been shown to increase HDL concentration in preclinical animal models and was targeted as a potential treatment of atherosclerosis. We describe… read more here.
Keywords: inhibitors endothelial; endothelial lipase; hdl; sulfonylated benzothiazoles ... See more keywords
Gene polymorphism associated with angiotensinogen (M235T), endothelial lipase (584C/T) and susceptibility to coronary artery disease: a meta-analysis
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DOI: 10.1042/bsr20201414
Abstract: Abstract Objective: To explore the association between the variant M235T locus of angiotensinogen (AGT) gene, 584C/T locus of Endothelial lipase (EL) gene, and coronary artery disease (CAD) by meta-analysis. Methods: The case–control studies on the… read more here.
Keywords: analysis; endothelial lipase; model; m235t ... See more keywords
Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abb0602
Abstract: Neutralization of endothelial lipase with a monoclonal antibody raises functional HDL in both nonhuman primates and in healthy humans. Limiting lipase to control cholesterol Strategies to reduce low-density lipoprotein cholesterol (LDL-C) while promoting high-density lipoprotein… read more here.
Keywords: density lipoprotein; antibody; endothelial lipase; hdl ... See more keywords
A Proof-of-Concept Inhibitor of Endothelial Lipase Suppresses Triple-Negative Breast Cancer Cells by Hijacking the Mitochondrial Function
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DOI: 10.3390/cancers14153763
Abstract: Simple Summary Endothelial lipase (EL/LIPG) is a key regulator of tumor cell metabolism. In triple-negative breast cancer (TNBC) cells, we find that the expression of LIPG is associated with long non-coding RNA DANCR and positively… read more here.
Keywords: metabolism; triple negative; endothelial lipase; tnbc ... See more keywords
Endothelial lipase promotes acute myeloid leukemia progression through metabolic reprogramming.
Sign Up to like & getrecommendations! Published in 2022 at "Neoplasma"
DOI: 10.4149/neo_2022_211004n1408
Abstract: Metabolic reprogramming occurs in the clonal evolution of acute myeloid leukemia (AML), which contributes to cell survival under metabolic stress and the development of drug resistance. Leukemic cells exhibit various metabolic profiles, which involve multiple… read more here.
Keywords: myeloid leukemia; myeloid; metabolic reprogramming; acute myeloid ... See more keywords