βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12638
Abstract: Endothelial–mesenchymal transition (EndMT) has emerged as an essential bioprocess responsible for the development of organ fibrosis. We have previously reported that fibroblast growth factor receptor 1 (FGFR1) is involved in the anti‐EndMT effect of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline… read more here.
Keywords: klb; mesenchymal transition; endmt; endothelial mesenchymal ... See more keywords
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition
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DOI: 10.1007/s11010-017-2956-6
Abstract: The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts… read more here.
Keywords: endothelial mesenchymal; huvecs; cardiac fibroblasts; activation ... See more keywords
Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108182
Abstract: Endothelial dysfunction accompanied by the loss of endothelial cell phenotype plays an essential role in cardiovascular diseases. Here, we report that inhibition of biliverdin reductase (BVR), the enzyme of the heme degradation pathway converting biliverdin… read more here.
Keywords: mesenchymal transition; endothelial mesenchymal; biliverdin reductase; endothelial cells ... See more keywords
NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.155
Abstract: Endothelial-to-mesenchymal transition (EndMT) of glomerular vascular endothelial cells (GEnCs) is now considered to play a critical role in diabetic nephropathy (DN). NOD2 is newly discovered to be closely related to DN renal injury. However, the… read more here.
Keywords: mek erk; mesenchymal transition; endothelial mesenchymal; diabetic nephropathy ... See more keywords
Endothelial-to-mesenchymal transition: pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases.
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DOI: 10.1016/j.bcp.2019.06.021
Abstract: Endothelial-to-mesenchymal transition (EndoMT) is a process of transdifferentiation where endothelial cells gradually adopt the phenotypic characteristics of mesenchymal cells. This phenomenon was first discovered in embryonic heart development. The mechanisms underlying EndoMT are due to… read more here.
Keywords: mesenchymal transition; endothelial mesenchymal; pathogenesis; endomt ... See more keywords
NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.10.034
Abstract: As the endothelial-to-mesenchymal transition (EndMT) supports the pro-angiogenic and invasive characteristics of glioblastoma multiforme (GBM), blocking this process would be a promising approach to inhibit tumor progression and recurrence. Here, we demonstrate that glioma stem… read more here.
Keywords: mesenchymal transition; endothelial mesenchymal; brain endothelial; endothelial cells ... See more keywords
LncRNA Gm16410 regulates PM2.5-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
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DOI: 10.1016/j.ecoenv.2020.111327
Abstract: Exposure to PM2.5 can cause serious harm to the respiratory system. Until now, although many toxicological studies have shown that pulmonary fibrosis can be caused by long-term PM2.5 exposure, there is no evidence that Endothelial-Mesenchymal… read more here.
Keywords: endothelial mesenchymal; gm16410; biology; lncrna gm16410 ... See more keywords
A Multiscale In Silico Model of Endothelial to Mesenchymal Transformation in a Tumor Microenvironment.
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DOI: 10.1016/j.jtbi.2019.08.012
Abstract: Endothelial to mesenchymal transformation (EndMT) is a process in which endothelial cells gain a mesenchymal-like phenotype in response to mechanobiological signals that results in the remodeling or repair of underlying tissue. While initially associated with… read more here.
Keywords: endothelial mesenchymal; mesenchymal transformation; model; tumor microenvironment ... See more keywords
Platelets induce endothelial-mesenchymal transition and subsequent fibrogenesis in endometriosis.
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DOI: 10.1016/j.rbmo.2020.03.020
Abstract: RESEARCH QUESTION Do endometriotic lesions undergo endothelial-mesenchymal transition (EndoMT)? DESIGN Lesion samples from 30 patients with ovarian endometriomas and deep endometriosis, and control endometrial tissue samples from 30 women without endometriosis, were analysed. In-vitro experimentation… read more here.
Keywords: endometriosis; mesenchymal transition; induce endothelial; platelets induce ... See more keywords
Meso-Endothelial Bipotent Progenitors from Human Placenta Display Distinct Molecular and Cellular Identity
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DOI: 10.1016/j.stemcr.2018.01.011
Abstract: Summary The existence of bipotential precursors for both mesenchymal and endothelial stem/progenitor cells in human postnatal life is debated. Here, we hypothesized that such progenitors are present within the human term placenta. From a heterogeneous… read more here.
Keywords: endothelial mesenchymal; endothelial bipotent; bipotent; human placenta ... See more keywords
Editorial commentary: Endothelial-to-mesenchymal transition: When the good one goes bad.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cardiovascular medicine"
DOI: 10.1016/j.tcm.2017.03.008
Abstract: The inner lumen of the blood vessels is covered by a thin layer of cells, known as endothelial cells. The integrity of endothelial cells is important for the development of the cardiovascular system and for… read more here.
Keywords: medicine; mesenchymal transition; endmt; endothelial mesenchymal ... See more keywords