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   Articles with "endothelial mesenchymal" as a keyword



Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

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recommendations! Published in 2025 at "Molecular Oncology"

DOI: 10.1002/1878-0261.70057

Abstract: Endothelial‐to‐mesenchymal transition (EndMT) is closely associated with tumor progression. Endothelial cells (ECs) in the tumor microenvironment (TME) use EndMT programs to facilitate tumor progression; however, the underlying mechanisms in ovarian cancer are poorly understood. Here,… read more here.

Keywords: mesenchymal transition; tumor microenvironment; primary cilia; tumor ... See more keywords

βklotho is essential for the anti‐endothelial mesenchymal transition effects of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12638

Abstract: Endothelial–mesenchymal transition (EndMT) has emerged as an essential bioprocess responsible for the development of organ fibrosis. We have previously reported that fibroblast growth factor receptor 1 (FGFR1) is involved in the anti‐EndMT effect of N‐acetyl‐seryl‐aspartyl‐lysyl‐proline… read more here.

Keywords: klb; mesenchymal transition; endmt; endothelial mesenchymal ... See more keywords

Exercise Induced Endothelial Mesenchymal Transition (EndMT) Facilitates Meniscal Fibrocartilage Regeneration

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202403788

Abstract: The meniscus is a semilunar wedge‐shaped fibrocartilage tissue within the knee joint that is important for withstanding mechanical shock during joint motion. The intrinsic healing capacity of meniscus tissue is very limited, which makes meniscectomy… read more here.

Keywords: mesenchymal transition; fibrocartilage; meniscus; endmt ... See more keywords

Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition

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recommendations! Published in 2017 at "Molecular and Cellular Biochemistry"

DOI: 10.1007/s11010-017-2956-6

Abstract: The aim of this study is to investigate the effect of evodiamine on fibroblast activation in cardiac fibroblasts and endothelial to mesenchymal transition (EndMT) in human umbilical vein endothelial cells (HUVECs). Neonatal rat cardiac fibroblasts… read more here.

Keywords: endothelial mesenchymal; huvecs; cardiac fibroblasts; activation ... See more keywords

Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.

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recommendations! Published in 2019 at "Archives of biochemistry and biophysics"

DOI: 10.1016/j.abb.2019.108182

Abstract: Endothelial dysfunction accompanied by the loss of endothelial cell phenotype plays an essential role in cardiovascular diseases. Here, we report that inhibition of biliverdin reductase (BVR), the enzyme of the heme degradation pathway converting biliverdin… read more here.

Keywords: mesenchymal transition; endothelial mesenchymal; biliverdin reductase; endothelial cells ... See more keywords

NOD2 promotes endothelial-to-mesenchymal transition of glomerular endothelial cells via MEK/ERK signaling pathway in diabetic nephropathy.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.01.155

Abstract: Endothelial-to-mesenchymal transition (EndMT) of glomerular vascular endothelial cells (GEnCs) is now considered to play a critical role in diabetic nephropathy (DN). NOD2 is newly discovered to be closely related to DN renal injury. However, the… read more here.

Keywords: mek erk; mesenchymal transition; endothelial mesenchymal; diabetic nephropathy ... See more keywords

Endothelial-to-mesenchymal transition: pathogenesis and therapeutic targets for chronic pulmonary and vascular diseases.

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recommendations! Published in 2019 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2019.06.021

Abstract: Endothelial-to-mesenchymal transition (EndoMT) is a process of transdifferentiation where endothelial cells gradually adopt the phenotypic characteristics of mesenchymal cells. This phenomenon was first discovered in embryonic heart development. The mechanisms underlying EndoMT are due to… read more here.

Keywords: mesenchymal transition; endothelial mesenchymal; pathogenesis; endomt ... See more keywords

NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma.

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.10.034

Abstract: As the endothelial-to-mesenchymal transition (EndMT) supports the pro-angiogenic and invasive characteristics of glioblastoma multiforme (GBM), blocking this process would be a promising approach to inhibit tumor progression and recurrence. Here, we demonstrate that glioma stem… read more here.

Keywords: mesenchymal transition; endothelial mesenchymal; brain endothelial; endothelial cells ... See more keywords
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LncRNA Gm16410 regulates PM2.5-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.

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recommendations! Published in 2020 at "Ecotoxicology and environmental safety"

DOI: 10.1016/j.ecoenv.2020.111327

Abstract: Exposure to PM2.5 can cause serious harm to the respiratory system. Until now, although many toxicological studies have shown that pulmonary fibrosis can be caused by long-term PM2.5 exposure, there is no evidence that Endothelial-Mesenchymal… read more here.

Keywords: endothelial mesenchymal; gm16410; biology; lncrna gm16410 ... See more keywords

A Multiscale In Silico Model of Endothelial to Mesenchymal Transformation in a Tumor Microenvironment.

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recommendations! Published in 2019 at "Journal of theoretical biology"

DOI: 10.1016/j.jtbi.2019.08.012

Abstract: Endothelial to mesenchymal transformation (EndMT) is a process in which endothelial cells gain a mesenchymal-like phenotype in response to mechanobiological signals that results in the remodeling or repair of underlying tissue. While initially associated with… read more here.

Keywords: endothelial mesenchymal; mesenchymal transformation; model; tumor microenvironment ... See more keywords

Platelets induce endothelial-mesenchymal transition and subsequent fibrogenesis in endometriosis.

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recommendations! Published in 2020 at "Reproductive biomedicine online"

DOI: 10.1016/j.rbmo.2020.03.020

Abstract: RESEARCH QUESTION Do endometriotic lesions undergo endothelial-mesenchymal transition (EndoMT)? DESIGN Lesion samples from 30 patients with ovarian endometriomas and deep endometriosis, and control endometrial tissue samples from 30 women without endometriosis, were analysed. In-vitro experimentation… read more here.

Keywords: endometriosis; mesenchymal transition; induce endothelial; platelets induce ... See more keywords