A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
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DOI: 10.1111/bph.13728
Abstract: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS‐derived NO and ROS signalling in vascular physiology. To determine the physiological requirement for de novo endothelial cell BH4 synthesis for the… read more here.
Keywords: endothelial cell; tetrahydrobiopterin; resistance arteries; endothelial nos ... See more keywords
Heat shock protein‐27 and sex‐selective regulation of muscarinic and proteinase‐activated receptor 2‐mediated vasodilatation: differential sensitivity to endothelial NOS inhibition
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DOI: 10.1111/bph.14200
Abstract: Previously, we demonstrated that exogenous heat shock protein 27 (HSP27/gene, HSPB1) treatment of human endothelial progenitor cells (EPCs) increases the synthesis and secretion of VEGF, improves EPC‐migration/re‐endothelialization and decreases neo‐intima formation, suggesting a role for… read more here.
Keywords: endothelial nos; heat shock; activated receptor; shock protein ... See more keywords