81 Development of adverse cardiac remodelling in experimental diabetes is regulated by endothelial NOX4 nadph oxidase
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DOI: 10.1136/heartjnl-2018-bcs.81
Abstract: Background The characteristic structural and functional cardiac abnormalities which occur in diabetes, including fibrosis, inflammation and microvascular remodelling, and result in increased susceptibility to cardiovascular stress are largely mediated by reactive oxygen species (ROS) generation.… read more here.
Keywords: adverse cardiac; endothelial nox4; cardiac remodelling; nox4 nadph ... See more keywords
Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes.
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DOI: 10.2337/db22-0194
Abstract: NADPH oxidase 4 (Nox4) is a major source of reactive oxygen species (ROS) in retinal endothelial cells (ECs) and is upregulated under hyperglycemic and hypoxic conditions. However, the role of endothelial Nox4 upregulation in long-term… read more here.
Keywords: vascular pathology; retinal vascular; pathology; endothelial nox4 ... See more keywords