Memantine protects against ischemia/reperfusion‐induced brain endothelial permeability
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1729
Abstract: Increased transendothelial permeability and subsequent blood–brain barrier damage play a key role in the pathological progression of human brain ischemia and secondary reperfusion. Memantine is a licensed drug providing clinically relevant efficacy in patients with… read more here.
Keywords: endothelial permeability; reperfusion; expression; brain ... See more keywords
The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy
Sign Up to like & getrecommendations! Published in 2017 at "Acta Diabetologica"
DOI: 10.1007/s00592-017-0985-y
Abstract: AbstractAims To investigate the consequences of oxidative stress and hypoxia on EPAC-1 expression during retinopathy.MethodsOxygen-induced retinopathy was induced in mice and EPAC-1 expression investigated by immunofluorescence. In silico analyses were used to identify a link… read more here.
Keywords: endothelial permeability; epac expression; expression; epac ... See more keywords
Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.11.058
Abstract: BACKGROUND Increased endothelial permeability is central to shock and organ dysfunction in sepsis but therapeutics targeted to known mediators of increased endothelial permeability have been unsuccessful in patient studies. We previously reported that cell-free hemoglobin… read more here.
Keywords: ascorbate; endothelial permeability; cell free; permeability ... See more keywords
Endothelial cell-cell adhesion and signaling
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.06.003
Abstract: Abstract Endothelial cells line blood vessels and provide a dynamic interface between the blood and tissues. They remodel to allow leukocytes, fluid and small molecules to enter tissues during inflammation and infections. Here we compare… read more here.
Keywords: cell; endothelial permeability; endothelial cell; cell adhesion ... See more keywords
Nanoparticle Density: A Critical Biophysical Regulator of Endothelial Permeability.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.6b07806
Abstract: The integrity of the vasculature system is intrinsically sensitive to a short list of biophysical cues spanning from nano to micro scales. We have earlier found that certain nanomaterials could induce endothelial leakiness (nanoparticle induced… read more here.
Keywords: endothelial permeability; nanoparticle density; endothelial leakiness; density ... See more keywords
Primary cilia control endothelial permeability by regulating expression and location of junction proteins.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab165
Abstract: AIMS Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair… read more here.
Keywords: junction; endothelial permeability; pkd patients; primary cilia ... See more keywords
SHOCK INDUCES ENDOTHELIAL PERMEABILITY AFTER TRAUMA THROUGH INCREASED ACTIVATION OF RHOA GTPASE
Sign Up to like & getrecommendations! Published in 2022 at "Shock"
DOI: 10.1097/shk.0000000000002008
Abstract: ABSTRACT Introduction: Severely injured patients develop a dysregulated inflammatory state characterized by vascular endothelial permeability, which contributes to multiple organ failure. To date, however, the mediators of and mechanisms for this permeability are not well… read more here.
Keywords: trauma; endothelial permeability; permeability; shock ... See more keywords
A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.aba2940
Abstract: A pathway underlying the TNFα-induced decrease in endothelial barrier function is found in veins but not arteries. The source of the leak in sepsis A challenge in treating sepsis, a potentially life-threatening, systemic inflammatory disorder,… read more here.
Keywords: tnf; endothelial permeability; tnf induced; permeability ... See more keywords
PV1: Gatekeeper of Endothelial Permeability
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2020-0294ed
Abstract: Endothelium is a monolayer of endothelial cells that lines the inner surface of blood vessels and plays a critical role in the maintenance of blood-vessel function and homeostasis. The endothelium is a semipermeable barrier that… read more here.
Keywords: endothelial permeability; permeability; caveolae mediated; transcytosis ... See more keywords
Vascular permeability in the fibrotic lung
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.00100-2019
Abstract: Idiopathic pulmonary fibrosis (IPF) is thought to result from aberrant tissue repair processes in response to chronic or repetitive lung injury. The origin and nature of the injury, as well as its cellular and molecular… read more here.
Keywords: endothelial permeability; fibrotic lung; permeability; lung injury ... See more keywords
Haemodynamic Wall Shear Stress, Endothelial Permeability and Atherosclerosis—A Triad of Controversy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.836680
Abstract: A striking feature of atherosclerosis is its patchy distribution within the vascular system; certain arteries and certain locations within each artery are preferentially affected. Identifying the local risk factors underlying this phenomenon may lead to… read more here.
Keywords: wall shear; endothelial permeability; atherosclerosis; permeability ... See more keywords