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Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPARγ Activity Under Disturbed Flow in Mice.

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2 Published in 2023 at "Arteriosclerosis, thrombosis, and vascular biology"

DOI: 10.1161/atvbaha.122.318173

Abstract: BACKGROUND Numerous genome-wide association studies revealed that SNPs at the PHACTR1 (phosphatase and actin regulator 1) locus strongly correlate with coronary artery disease. However, the biological function of PHACTR1 remains poorly understood. Here, we identified… read more here.

Keywords: phactr1; disturbed flow; atherosclerosis; mice ... See more keywords