H2O2 down-regulates SIRT7’s protective role of endothelial premature dysfunction via microRNA-335-5p
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211775
Abstract: Abstract Endothelial senescence is believed to constitute the initial pathogenesis of the atherosclerotic cardiovascular disease (ASCVD). MicroRNA-335-5p (miR-335-5p) expression is significantly up-regulated in oxidative stress-induced endothelial cells (ECs). Sirtuin7 (SIRT7) is considered to prevent EC… read more here.
Keywords: mir 335; microrna 335; sirt7; senescence ... See more keywords
Endothelial Senescence: A New Age in Pulmonary Hypertension
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DOI: 10.1161/circresaha.121.319815
Abstract: Pulmonary hypertension is an enigmatic, deleterious disease driven by multiple heterogeneous causes with a burgeoning proportion of older patients with complex, chronic comorbidities without adequate treatment options. The underlying endothelial pathophenotypes that direct vasoconstriction and… read more here.
Keywords: senescence new; endothelial senescence; hypertension; age ... See more keywords
Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence
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DOI: 10.1371/journal.pone.0192252
Abstract: L-citrulline and L-arginine supplementation has been shown to have several beneficial effects on the cardiovascular system. Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which converts… read more here.
Keywords: supplementation; conditions cit; senescence; cit lalc ... See more keywords
Endothelial Senescence in Neurological Diseases.
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DOI: 10.14336/ad.2023.0226-1
Abstract: Endothelial cells, which are highly dynamic cells essential to the vascular network, play an indispensable role in maintaining the normal function of the body. Several lines of evidence indicate that the phenotype associated with senescent… read more here.
Keywords: senescence; endothelial senescence; senescence neurological; neurological diseases ... See more keywords
Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities
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DOI: 10.3389/fphys.2021.693067
Abstract: Cellular senescence is a stable form of cell cycle arrest in response to various stressors. While it serves as an endogenous pro-resolving mechanism, detrimental effects ensue when it is dysregulated. In this review, we introduce… read more here.
Keywords: long noncoding; vascular endothelial; senescence; pathobiological insights ... See more keywords
Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12020215
Abstract: Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation. These factors are increased in the elderly and from chronic disease… read more here.
Keywords: diseases challenges; chronic vascular; senescence; endothelial senescence ... See more keywords