Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprung’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Surgery International"
DOI: 10.1007/s00383-017-4180-6
Abstract: PurposeLaminin, an extracellular matrix molecule, is essential for normal development of the nervous system. The alpha1 subunit of laminin-1 (LAMA1) has been reported to promote neurites and outgrowth and is expressed only during embryogenesis. Previously,… read more here.
Keywords: endothelin receptor; expression; laminin; colon ... See more keywords
Effects of endothelin receptor blockade and COX inhibition on intestinal I/R injury in a rat model: Experimental research.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of surgery"
DOI: 10.1016/j.ijsu.2020.08.061
Abstract: BACKGROUND Intestinal ischemia is a highly morbid and mortal condition with no specific treatment. The present study aimed to investigate the effects of cyclooxygenase (COX) inhibition synchronized with nitric oxide (NO) release and endothelin (ET)… read more here.
Keywords: receptor blockade; treatment; endothelin receptor; intestinal injury ... See more keywords
Simultaneous quantification of endothelin receptor antagonists and phosphodiesterase 5 inhibitors currently used in pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.05.052
Abstract: &NA; Combination treatment with endothelin receptor antagonists (ERA) and phosphodiesterase 5 inhibitors (PDE5I) improved efficacy of pulmonary arterial hypertension (PAH) therapy. However, drug–drug interactions, variable exposure, non‐adherence can influence plasma levels. For these reasons, drug… read more here.
Keywords: drug; endothelin receptor; pulmonary arterial; receptor antagonists ... See more keywords
Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity, Developability, and Serum Persistence Exhibits Excellent Antitumor Potency.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00923
Abstract: Endothelin receptor A (ETA), a class A G protein-coupled receptor (GPCR), is a promising tumor-associated antigen due to its close association with the progression and metastasis of many types of cancer, such as colorectal, breast,… read more here.
Keywords: eta; binding affinity; antibody; endothelin receptor ... See more keywords
The potential benefit of endothelin receptor antagonists’ therapy in idiopathic pulmonary fibrosis: A meta-analysis of results from randomized controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000029981
Abstract: Background: Fibrotic diseases take a very heavy toll in terms of morbidity and mortality equal to or even greater than that caused by metastatic cancer. This meta-analysis aimed to evaluate the effect of endothelin receptor… read more here.
Keywords: receptor antagonists; meta analysis; idiopathic pulmonary; endothelin receptor ... See more keywords
Effectiveness and safety of endothelin receptor antagonists, alone and in combination therapy, in the pulmonary arterial hypertension‐connective tissue disease subtype: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.13916
Abstract: There is limited information regarding the effectiveness of endothelin receptor antagonists (ERA) in patients with connective tissue disease‐pulmonary arterial hypertension (CTD‐PAH), a condition that is characterized by poorer clinical outcomes compared to other PAH subtypes. read more here.
Keywords: connective tissue; pulmonary arterial; endothelin receptor; tissue disease ... See more keywords
Endothelin‐1 receptor blockade as new possible therapeutic approach in multiple myeloma
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DOI: 10.1111/bjh.14771
Abstract: New effective treatments are needed to improve outcomes for multiple myeloma (MM) patients. Receptors with restricted expression on plasma cells (PCs) represent attractive new therapeutic targets. The endothelin‐1 (EDN1) axis, consisting of EDN1 acting through… read more here.
Keywords: malignant pcs; receptor blockade; multiple myeloma; endothelin receptor ... See more keywords
Knockdown of endothelin receptor B inhibits the progression of triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14039
Abstract: Endothelin receptor B (EDNRB) is one of the receptors in the endothelin axis and its upregulated expression is associated with tumorigenesis and metastasis of several types of solid tumors. However, the expression profile of EDNRB… read more here.
Keywords: negative breast; breast cancer; endothelin receptor; cancer ... See more keywords
Decreased endothelin receptor A autoantibody levels are associated with early ischaemic events in patients with giant-cell arteritis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-215341
Abstract: Endothelin 1 (ET-1) is a potent vasoactive peptide hormone produced by endothelial cells, macrophages and vascular smooth muscle cells (VSMCs). Elevated ET-1 plasma levels have been reported in patients with ischaemic complications in giant-cell arteritis… read more here.
Keywords: giant cell; cell arteritis; endothelin receptor; receptor autoantibody ... See more keywords
Chondroitin sulfate mediates liver responses to injury induced by dual endothelin receptor inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2019-0649
Abstract: Although dual endothelin receptor antagonists (ERAs) show great promise for treating various conditions, their propensity to induce liver injury limits their clinical usage. Inflammation and fibrosis are important processes in liver responses to injury and… read more here.
Keywords: inhibition; dual endothelin; endothelin receptor; chst3 chst13 ... See more keywords
Endothelin-1 receptor blockade does not alter the sympathetic and hemodynamic response to acute intermittent hypoxia in men.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00837.2021
Abstract: Repeat exposures to low oxygen (intermittent hypoxia, IH), like that observed in sleep apnea, elicit increases in muscle sympathetic nerve activity (MSNA) and blood pressure (BP) in men. Endothelin (ET) receptor antagonists can attenuate the… read more here.
Keywords: receptor; endothelin receptor; msna; intermittent hypoxia ... See more keywords