Improved Endothelium-Dependent Relaxation of Thoracic Aorta in Niclosamide-Treated Diabetic Rats.
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DOI: 10.1007/s12012-021-09647-0
Abstract: Diabetes-induced endothelial dysfunction is critical for the development of diabetic cardiovascular complications. The aim of this study was to investigate the effect of niclosamide (Nic) on vascular endothelial dysfunction in streptozotocin (STZ)-induced diabetic rats. Male… read more here.
Keywords: relaxation; endothelium dependent; treated diabetic; thoracic ... See more keywords
Endothelium‐dependent relaxation by a hydroethanolic extract of Adansonia digitata leaves in porcine coronary artery rings and rat thoracic aorta, mesenteric, carotid artery rings: Role of NO and EDH: O11
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DOI: 10.1016/j.bcp.2017.06.076
Abstract: Introduction Adansonia digitata leaves are used for the traditional treatment of hypertension in Senegal. This study evaluated the relaxant effect of a hydroethanolic extract of leaves of Adansonia digitata (ADF) in artery rings, and investigated… read more here.
Keywords: artery; endothelium dependent; adansonia digitata; artery rings ... See more keywords
Endothelium‐dependent contractions depending on biased sGC activation: The Janus face of thymoquinone: O36
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DOI: 10.1016/j.bcp.2017.06.101
Abstract: Objective Thymoquinone, a major component of black seed oil, has beneficial (vasodilator, antioxidative and anti-inflammatory) effects in the cardiovascular system. Previous experiments in isolated arteries indicate that thymoquinone causes augmentations of contraction. The present study… read more here.
Keywords: endothelium; endothelium dependent; thymoquinone; biased sgc ... See more keywords
Endothelial cell transient receptor potential channel C5 (TRPC5) is essential for endothelium‐dependent contraction in mouse carotid arteries
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DOI: 10.1016/j.bcp.2018.11.002
Abstract: &NA; Augmented endothelium‐dependent contractions (EDC) contributes to endothelial dysfunction and vascular disease progression. An early signal in EDC is cytosolic [Ca2+]i rise in endothelial cells, which stimulates the production of contractile prostanoids, leading to vascular… read more here.
Keywords: endothelium dependent; carotid arteries; trpc5; mouse carotid ... See more keywords
Chronic ethanol consumption enhances inducible endothelium-dependent hyperpolarizing factor-mediated relaxation in the rat artery.
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DOI: 10.1016/j.ejphar.2019.172759
Abstract: The inducible endothelium-dependent hyperpolarizing factor (iEDHF) pathway is activated as a compensatory response to adverse changes in the body. It causes vasorelaxation and maintains circulatory homeostasis in the organs. Small to moderate quantities of ethanol… read more here.
Keywords: inducible endothelium; relaxation; endothelium dependent; group ... See more keywords
Improvement of penile neurogenic and endothelial relaxant responses by chronic administration of resveratrol in rabbits exposed to unpredictable chronic mild stress
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DOI: 10.1038/s41443-018-0016-8
Abstract: Chronic stress is an important public health problem known as a risk factor for depression, cognitive deficits, and also erectile dysfunction (ED). Resveratrol, a plant polyphenol, was reported to activate constitutive endothelial nitric oxide synthase… read more here.
Keywords: resveratrol; endothelium dependent; stress; chronic mild ... See more keywords
Associations of resting heart rate with endothelium-dependent vasodilation and shear rate
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DOI: 10.1080/10641963.2016.1226890
Abstract: ABSTRACT Heart rate is an independent risk factor for cardiovascular disease and a hemodynamic factor that can modulate blood flow as it affects the frequency of shear stimuli acting on the arterial wall. However, the… read more here.
Keywords: heart rate; rate; dependent vasodilation; endothelium dependent ... See more keywords
MATERNAL SALT INTAKE AND MICROVASCULAR ENDOTHELIAL FUNCTION DURING THE THIRD TRIMESTER OF HEALTHY PREGNANCY
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DOI: 10.1097/01.hjh.0000838352.15587.d4
Abstract: Objective: Even in healthy individuals, high-salt (HS) loading leads to endothelial dysfunction, a hallmark of cardiometabolic diseases, independently of the changes in blood pressure (BP). Still, the effect of the amount of daily salt intake… read more here.
Keywords: healthy pregnancy; salt intake; endothelium dependent; daily salt ... See more keywords
PERMISSIVE ROLE OF ANGIOTENSIN II IN MANTENANCE OF ENDOTHELIUM-DEPENDENT VASODILATION IN CEREBRAL MICROCIRCULATION
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DOI: 10.1097/01.hjh.0000838440.67547.4c
Abstract: Objective: A number of data suggest, rather controversial, permissive role of angiotensin II (ANGII) in maintaining vasodilator responses in microcirculation, via its interaction with AT1 receptors (AT1R). This study aimed to determine the role of… read more here.
Keywords: stress; permissive role; oxidative stress; role angiotensin ... See more keywords
Proteomic profiling of endothelium-dependent vasodilation
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DOI: 10.1097/hjh.0000000000001863
Abstract: Objective: As endothelial dysfunction is an early event in atherosclerosis formation, we investigated if proteins previously related to cardiovascular disease also were related to endothelial function using a novel targeted proteomics approach. Methods: In the… read more here.
Keywords: profiling endothelium; endothelium dependent; proteomic profiling; dependent vasodilation ... See more keywords
Increased inward rectifier K+ current of coronary artery smooth muscle cells in spontaneously hypertensive rats; partial compensation of the attenuated endothelium‐dependent relaxation via Ca2+‐activated K+ channels
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DOI: 10.1111/1440-1681.13168
Abstract: Endothelium‐dependent vasorelaxation is partly mediated by small‐conductance (SK3) and intermediate‐conductance Ca2+‐activated K+ channels (SK4) in the endothelium that results in endothelium‐dependent hyperpolarization (EDH). Apart from the electrical propagation through myoendothelial gap junctions, the K+ released… read more here.
Keywords: relaxation; endothelium dependent; muscle cells; smooth muscle ... See more keywords