Widespread time-dependent changes in tissue cytokine concentrations in brain regions during the acute phase of endotoxemia in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2019.10.006
Abstract: Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction induced by the systemic response to infection in septic patients. In the present study, we modeled SAE by administering lipopolysaccharide (LPS) intraperitoneally to mice at a concentration… read more here.
Keywords: acute phase; lps injection; endotoxemia; brain regions ... See more keywords
Low molecular weight heparin reduces acute phase response and multiple organ dysfunction following Ovine experimental endotoxemia model.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2021.110361
Abstract: Endotoxemia is one of the most common inflammatory situations leading to death of ruminants. Owing to the importance of this condition, several therapeutic regimens have been proposed, evaluated and implemented to treat endotoxemia. It has… read more here.
Keywords: endotoxemia; low molecular; weight heparin; molecular weight ... See more keywords
MicroRNA-674-5p induced by HIF-1α targets XBP-1 in intestinal epithelial cell injury during endotoxemia
Sign Up to like & getrecommendations! Published in 2020 at "Cell Death Discovery"
DOI: 10.1038/s41420-020-0280-5
Abstract: Intestinal mucosal integrity dysfunction during endotoxemia can contribute to translocation of intestinal bacteria and a persistent systemic inflammatory response, which both fuel the pathophysiological development of sepsis or endotoxemia. The pathogenesis of intestinal damage induced… read more here.
Keywords: intestinal epithelial; mir 674; cell; endotoxemia ... See more keywords
Targeting β1-integrin inhibits vascular leakage in endotoxemia
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1722317115
Abstract: Significance Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking. Here, we show that targeting β1-integrin in vivo with inhibitory antibodies or deletion of a single… read more here.
Keywords: leakage; endotoxemia; vascular leakage; targeting integrin ... See more keywords
Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia
Sign Up to like & getrecommendations! Published in 2022 at "Periodontology 2000"
DOI: 10.1111/prd.12433
Abstract: Abstract Lipopolysaccharide is a virulence factor of gram‐negative bacteria with a crucial importance to the bacterial surface integrity. From the host's perspective, lipopolysaccharide plays a role in both local and systemic inflammation, activates both innate… read more here.
Keywords: cardiometabolic disorders; endotoxemia; periodontitis cardiometabolic; role ... See more keywords
Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Heart Association"
DOI: 10.1161/jaha.121.022482
Abstract: Background Translocation of lipopolysaccharide from gram-negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and obesity. Methods and Results We… read more here.
Keywords: endotoxemia; lipopolysaccharide activity; thromboembolism stroke; genetic profile ... See more keywords
Gut Dysbiosis Could Be a Major Factor for the Effects of Low-Grade Endotoxemia in COVID-19 Comment on: Low-Grade Endotoxemia and Thrombosis in COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Gastroenterology"
DOI: 10.14309/ctg.0000000000000440
Abstract: The intestinal microbiota plays a fundamental role inhumanhealth, particularly in immune system development and maintenance. Commensal bacteria and their metabolites not only promote immune responses but also provide anti-inflammatory mechanisms, establishing a strong but well-balanced… read more here.
Keywords: endotoxemia; dysbiosis; gut dysbiosis; anti inflammatory ... See more keywords
Galectin-9 Mediates the Therapeutic Effect of Mesenchymal Stem Cells on Experimental Endotoxemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.700702
Abstract: Endotoxemia remains a major cause of mortality in the intensive care unit, but the therapeutic strategy is still lacking. Mesenchymal stem cell (MSC) was reported with a tissue-oriented differentiation ability and an excellent immunoregulatory capacity.… read more here.
Keywords: mscs; experimental endotoxemia; endotoxemia; gal high ... See more keywords
Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.559671
Abstract: Introduction: Sepsis is the most prevalent cause of Acute Kidney Injury (AKI). Conversely, in some septic patients the glomerular filtration rate (GFR) is augmented. The role of the inflammatory response and blood pressure to induce… read more here.
Keywords: gfr; inflammatory mediators; blood pressure; endotoxemia ... See more keywords
Novel Combination of COX-2 Inhibitor and Antioxidant Therapy for Modulating Oxidative Stress Associated with Intestinal Ischemic Reperfusion Injury and Endotoxemia
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DOI: 10.3390/antiox9100930
Abstract: Background: Intestinal ischemic reperfusion (I/R) injury is associated with a high mortality rate; this condition is also related to significant endotoxemia and systemic inflammation. The preservation of tissue perfusion and a sufficient blood flow are… read more here.
Keywords: intestinal ischemic; endotoxemia; reperfusion; injury ... See more keywords
Myeloperoxidase-Derived 2-Chlorohexadecanal Is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21239235
Abstract: Sepsis is a major cause of mortality in critically ill patients and associated with cardiac dysfunction, a complication linked to immunological and metabolic aberrations. Cardiac neutrophil infiltration and subsequent release of myeloperoxidase (MPO) leads to… read more here.
Keywords: heart; mouse heart; formation; endotoxemia ... See more keywords