Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119836
Abstract: Neutrophil elastase (NE) is a serine protease stored in the azurophilic granules of neutrophils and released into the extracellular milieu during inflammatory response or formation of neutrophil extracellular traps (NETs). Neutrophils release NETs to entrap… read more here.
Keywords: neutrophil extracellular; formation; neutrophil elastase; endotoxic shock ... See more keywords
Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02701-1
Abstract: Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches. Here, we surveyed small-molecule compounds that efficiently inhibit the transcriptional activity… read more here.
Keywords: hif; mint3; tumour growth; endotoxic shock ... See more keywords
Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Trauma and Acute Care Surgery"
DOI: 10.1097/ta.0000000000002036
Abstract: BACKGROUND Hemorrhagic shock-induced changes in vascular reactivity appear organ-specific. In the present study, we examined the hypothesis that vascular reactivity induced by septic shock similarly displays organ-specific differences and is regulated by inducible nitric oxide… read more here.
Keywords: organ specific; changes vascular; vascular reactivity; reactivity ... See more keywords
Long Noncoding RNA U90926 Is Induced in Activated Macrophages, Is Protective in Endotoxic Shock, and Encodes a Novel Secreted Protein.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200215
Abstract: Thousands of long noncoding RNAs are encoded in mammalian genomes, yet most remain uncharacterized. In this study, we functionally characterized a mouse long noncoding RNA named U90926. Analysis of U90926 RNA levels revealed minimal expression… read more here.
Keywords: rna; long noncoding; endotoxic shock; protein ... See more keywords