The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1319040
Abstract: ABSTRACT Macroautophagy/autophagy is a central mechanism by which cells maintain integrity and homeostasis, and endotoxin-induced autophagy plays important roles in innate immunity. Although TLR4 stimulation mediated by lipopolysaccharide (LPS) also upregulates autophagy in hepatocytes and… read more here.
Keywords: endotoxin induced; metabolism; role; induced autophagy ... See more keywords
Induced pluripotent stem cells reduce neutrophil chemotaxis via activating GRK2 in endotoxin‐induced acute lung injury
Sign Up to like & getrecommendations! Published in 2017 at "Respirology"
DOI: 10.1111/resp.13053
Abstract: We investigated the effect of induced pluripotent stem cells (iPSCs) in moderating neutrophil chemotaxis in endotoxin‐induced acute lung injury (ALI). read more here.
Keywords: endotoxin induced; induced pluripotent; pluripotent stem; neutrophil chemotaxis ... See more keywords
High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice
Sign Up to like & getrecommendations! Published in 2017 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210413
Abstract: Background Elevated plasma levels of angiopoietin-2 (ANGPT2) have been reported in patients with acute lung injury (ALI); however, it remains unclear whether this increase contributes to, or just marks, the underlying vasculopathic inflammation and leak… read more here.
Keywords: endotoxin induced; vascular leak; leak; mice ... See more keywords
Morroniside Ameliorates Endotoxin-Induced Uveitis by Regulating the M1/M2 Polarization Balance of Macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/1252873
Abstract: Background Inflammation is closely associated with the pathogenesis of various ocular diseases. Uveitis is a condition characterized by the inflammation of the uvea and ocular tissues that causes extreme pain, decreases visual acuity, and may… read more here.
Keywords: morroniside; induced uveitis; expression; endotoxin induced ... See more keywords
Frontline Science: D1 dopaminergic receptor signaling activates the AMPK‐bioenergetic pathway in macrophages and alveolar epithelial cells and reduces endotoxin‐induced ALI
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.3hi0216-068rr
Abstract: Catecholamines, including β‐adrenergic and dopaminergic neurotransmitters, have an essential role in regulating the “fight or flight” reflex and also affects immune cell proinflammatory action. However, little is known about whether catecholamines prevent dysfunction of metabolic… read more here.
Keywords: endotoxin induced; induced ali; epithelial cells; activation ... See more keywords
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15413
Abstract: To investigate the effects and mechanism of diosmetin on acute hepatic failure (AHF), an AHF murine model was established through administration of lipopolysaccharides/D-galactosamine (LPS/D-GalN). In vitro, diosmetin scavenged free radicals. In vivo, diosmetin decreased mortality… read more here.
Keywords: endotoxin induced; acute hepatic; hepatic failure; diosmetin ... See more keywords
Anti-Inflammatory Effects of GM1 Ganglioside on Endotoxin-Induced Uveitis in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050727
Abstract: Exogenous ganglioside GM1 has been reported to exert an immunomodulatory effect. We investigated the anti-inflammatory effect of GM1 ganglioside on endotoxin-induced uveitis (EIU) in rats and RAW 264.7 macrophages. Methods: EIU was induced in Lewis… read more here.
Keywords: effect; gm1 ganglioside; anti inflammatory; ganglioside endotoxin ... See more keywords
Retinal Proteomic Analysis in a Mouse Model of Endotoxin-Induced Uveitis Using Data-Independent Acquisition-Based Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126464
Abstract: Uveitis is a group of sight-threatening ocular inflammatory diseases, potentially leading to permanent vision loss in patients. However, it remains largely unknown how uveitis causes retinal malfunction and vision loss. Endotoxin-induced uveitis (EIU) in rodents… read more here.
Keywords: retinal proteomic; induced uveitis; analysis; model ... See more keywords
Selective Cannabinoid 2 Receptor Agonists as Potential Therapeutic Drugs for the Treatment of Endotoxin-Induced Uveitis
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24183338
Abstract: (1) Background: The cannabinoid 2 receptor (CB2R) is a promising anti-inflammatory drug target and development of selective CB2R ligands may be useful for treating sight-threatening ocular inflammation. (2) Methods: This study examined the pharmacology of… read more here.
Keywords: endotoxin induced; ro6871304 ro6871085; selective cb2r; cannabinoid receptor ... See more keywords