Effects of Endotoxin Tolerance Induced by Porphyromonas gingivalis Lipopolysaccharide on Inflammatory Responses in Neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01243-8
Abstract: Periodontitis is a dental plaque–induced chronic inflammatory disease. Long-term exposure of the host to periodontal pathogens leads to a hyporesponsive state to the following stimulations, which is described as endotoxin tolerance. Neutrophils are the most… read more here.
Keywords: inflammatory responses; tolerance; gingivalis lps; tolerized neutrophils ... See more keywords
Extract from Coriolus versicolor fungus partially prevents endotoxin tolerance development by maintaining febrile response and increasing IL-6 generation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of thermal biology"
DOI: 10.1016/j.jtherbio.2019.05.005
Abstract: Endotoxin tolerance is defined as a reduced endotoxin-induced fever following repeated injections of lipopolysaccharide (LPS). Clinical examples of endotoxin tolerance include sepsis or cystic fibrosis. This state is characterized by inhibition of pro-inflammatory cytokines production… read more here.
Keywords: extract coriolus; endotoxin tolerance; tolerance; response ... See more keywords
Protective effects of endotoxin tolerance on peripheral lipopolysaccharide-induced neuroinflammation and dopaminergic neuronal injury
Sign Up to like & getrecommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2022.2043900
Abstract: Abstract Context Parkinson's disease is a common chronic neurodegenerative disease characterized by massive loss of dopaminergic neurons in the substantia nigra. Neuroinflammation has been shown to play an important role in the pathogenesis of neurodegenerative… read more here.
Keywords: dose lps; neuroinflammation; tolerance; high dose ... See more keywords
Repeated lipopolysaccharide exposure leads to placental endotoxin tolerance
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13080
Abstract: Placental infection induces increased levels of pro‐inflammatory cytokines, which have been implicated in the pathogenesis of pre‐term labor. Endotoxin tolerance is a phenomenon in which exposure to a dose of endotoxin makes tissue less responsive… read more here.
Keywords: endotoxin; exposure; repeated lipopolysaccharide; lipopolysaccharide exposure ... See more keywords
Human periodontal ligament cells exhibit no endotoxin tolerance upon stimulation with Porphyromonas gingivalis lipopolysaccharide
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DOI: 10.1111/jre.12549
Abstract: Background/Objectives Endotoxin tolerance is characterized by a state of hyporesponsiveness after confrontation with endotoxins such as lipopolysaccharides (LPS) at low concentrations. The aim of this study was to investigate, whether pretreatment with Porphyromonas gingivalis leads… read more here.
Keywords: periodontal ligament; tolerance; porphyromonas gingivalis; ligament cells ... See more keywords
c-Myb Dominates TBK1-Mediated Endotoxin Tolerance in Kupffer Cells by Negatively Regulating DTX4
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/5990156
Abstract: As a protective mechanism regulating excessive inflammation, endotoxin tolerance plays a vital role in regulating endotoxin shock. Kupffer cells are players in mediating endotoxin tolerance. Nonetheless, the regulatory mechanism regulating endotoxin tolerance is barely known.… read more here.
Keywords: endotoxin tolerance; tolerance kupffer; kupffer cells; tolerance ... See more keywords
Pharmacologic Induction of Endotoxin Tolerance in Dendritic Cells by L-Kynurenine
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00292
Abstract: Endotoxin tolerance aims at opposing hyperinflammatory responses to lipopolysaccharide (LPS) exposure. The aryl hydrocarbon receptor (AhR) participates in protection against LPS-mediated tissue damage, as it plays a necessary role in restraining the proinflammatory action of… read more here.
Keywords: tolerance; endotoxin; pharmacologic induction; dendritic cells ... See more keywords
Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.595316
Abstract: Pyruvate kinase M2 (PKM2) is a key glycolysis enzyme, and its effect on macrophages has not been entirely elucidated. Here, we identified that the PKM2 small-molecule agonist TEPP-46 mediated PKM2 activation by inducing the formation… read more here.
Keywords: mitochondrial biogenesis; pyruvate kinase; tolerance; pkm2 ... See more keywords
Endotoxin Tolerance Acquisition and Altered Hepatic Fatty Acid Profile in Aged Mice
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DOI: 10.3390/biology12040530
Abstract: Simple Summary Diseases that are characterized by inflammation such as sepsis, fatty liver or severe COVID-19 are more critical in the elderly population. Endotoxin tolerance is a tolerance towards pathogen components like lipopolysaccharides from bacterial… read more here.
Keywords: endotoxin tolerance; fatty acid; old mice; tolerance ... See more keywords