CYP2D6 genotype and endoxifen plasma concentration do not predict hot flash severity during tamoxifen therapy
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4876-x
Abstract: PurposeTamoxifen is frequently prescribed to prevent breast cancer recurrence. Tamoxifen is a prodrug and requires bioactivation by CYP2D6. Tamoxifen use is often limited by adverse effects including severe hot flashes. There is paucity of prospectively… read more here.
Keywords: flash severity; endoxifen; tamoxifen therapy; hot flash ... See more keywords
Skeletal and Uterotrophic Effects of Endoxifen in Female Rats
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DOI: 10.1210/en.2016-1871
Abstract: &NA; Endoxifen, the primary active metabolite of tamoxifen, is currently being investigated as a novel endocrine therapy for the treatment of breast cancer. Tamoxifen is a selective estrogen receptor modulator that elicits potent anti‐breast cancer… read more here.
Keywords: breast cancer; tamoxifen; bone loss; cancer ... See more keywords