circRNA_0058097 promotes tension‐induced degeneration of endplate chondrocytes by regulating HDAC4 expression through sponge adsorption of miR‐365a‐5p
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29202
Abstract: Excessive mechanical tension can lead to the degeneration of endplate chondrocytes. The presence of tension‐sensitive circRNA_0058097 molecules has been detected in human endplate chondrocytes, where it was found to be a potential competing endogenous RNA.… read more here.
Keywords: degeneration endplate; endplate chondrocytes; circrna 0058097; endplate ... See more keywords
Development of a rat model with lumbar vertebral endplate lesion
Sign Up to like & getrecommendations! Published in 2022 at "European Spine Journal"
DOI: 10.1007/s00586-022-07148-4
Abstract: Vertebral endplate lesion (EPL) caused by severe disc degeneration is associated with low back pain. However, there is no suitable animal model to elucidate the pathophysiology of EPL. This study aimed to develop a rat… read more here.
Keywords: group; endplate; sham group; epl group ... See more keywords
Larger vertebral endplate concavities cause higher failure load and work at failure under high-rate impact loading of rabbit spinal explants.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2018.01.019
Abstract: Vertebral fractures are among the most common of all osteoporosis related fracture types and its risk assessment is largely based on bone quality measures. Morphometric parameters are not yet considered, although endplate thickness and concavity… read more here.
Keywords: rate impact; endplate; impact loading; high rate ... See more keywords
Effect of fibroblast growth factor 2 on degenerative endplate chondrocyte: From anabolism to catabolism.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104590
Abstract: BACKGROUND Endplate degeneration is characterized by an unbalance between the anabolism and catabolism of endplate chondrocyte (CH). Fibroblast growth factor 2 (FGF2) has been shown to promote cartilage repair by increasing articular CH anabolic activity.… read more here.
Keywords: catabolism; fgf2; endplate; degeneration ... See more keywords
Endplate Defect Is Heritable, Associated With Low Back Pain and Triggers Intervertebral Disc Degeneration: A Longitudinal Study From TwinsUK
Sign Up to like & getrecommendations! Published in 2018 at "SPINE"
DOI: 10.1097/brs.0000000000002721
Abstract: Study Design. Longitudinal study of spine magnetic resonance imaging (MRI) in a large-scale population-based study. Objective. To determine the order of appearance of degenerative change in vertebral bodies and intervertebral discs. We also sought to… read more here.
Keywords: study; endplate; disc degeneration; endplate defect ... See more keywords
Cervical Spine Endplate Abnormalities and Association With Pain, Disability, and Adjacent Segment Degeneration After Anterior Cervical Discectomy and Fusion.
Sign Up to like & getrecommendations! Published in 2020 at "Spine"
DOI: 10.1097/brs.0000000000003460
Abstract: STUDY DESIGN A retrospective study with prospectively-collected data. OBJECTIVE To determine how type, location, and size of endplate lesions on magnetic resonance imaging (MRI) may be associated with symptoms and clinical outcomes after anterior cervical… read more here.
Keywords: location; endplate abnormalities; cervical spine; endplate ... See more keywords
The adjustable aiming device for caspar pin insertion in anterior cervical spine surgery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/10225536221077460
Abstract: Background Creating a rectangular disc space is an important step during anterior cervical discectomy and fusion or cervical total disc replacement. The study aims to determine the accuracy of Caspar pin insertion by using a… read more here.
Keywords: slope; caspar; anterior cervical; endplate ... See more keywords
Computed Tomography Osteoabsorptiometry Evaluation of Cervical Endplate Subchondral Bone Mineral Density.
Sign Up to like & getrecommendations! Published in 2021 at "Global spine journal"
DOI: 10.1177/21925682211050325
Abstract: STUDY DESIGN Basic Science. OBJECTIVE Poor subchondral bone mineral density (sBMD) has been linked with subsidence of cervical interbody devices or grafts, which are traditionally placed centrally on the endplates. Considering that sBMD reflects long-term… read more here.
Keywords: bone mineral; endplate; subchondral bone; density ... See more keywords
Quantifying Bone Marrow Edema Adjacent to the Lumbar Vertebral Endplate on Magnetic Resonance Imaging: A Cross-Sectional Study of Patients with Degenerative Lumbar Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Asian spine journal"
DOI: 10.31616/asj.2020.0648
Abstract: Study Design Cross-sectional study. Purpose We aimed to quantitatively assess bone marrow edema (BME) on magnetic resonance imaging (MRI) for patients with degenerative lumbar diseases. Overview of Literature BME adjacent to a sclerotic endplate of… read more here.
Keywords: degenerative lumbar; endplate; bone; patients degenerative ... See more keywords
Biomechanical Study of Cervical Endplate Removal on Subsidence and Migration in Multilevel Anterior Cervical Discectomy and Fusion.
Sign Up to like & getrecommendations! Published in 2022 at "Asian spine journal"
DOI: 10.31616/asj.2021.0424
Abstract: Study Design This study compares four cervical endplate removal procedures, validated by finite element models. Purpose To characterize the effect of biomechanical strength and increased contact area on the maximum von Mises stress, migration, and… read more here.
Keywords: study; endplate; endplate removal; migration ... See more keywords
The Endplate Role in Degenerative Disc Disease Research: The Isolation of Human Chondrocytes from Vertebral Endplate—An Optimised Protocol
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9040137
Abstract: Background: Degenerative disc disease is a progressive and chronic disorder with many open questions regarding its pathomorphological mechanisms. In related studies, in vitro organ culture systems are becoming increasingly essential as a replacement option for… read more here.
Keywords: human chondrocytes; chondrocytes vertebral; degenerative disc; disc disease ... See more keywords