TGF‐β/SMAD signaling inhibits intermittent cyclic mechanical tension‐induced degeneration of endplate chondrocytes by regulating the miR‐455‐5p/RUNX2 axis
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DOI: 10.1002/jcb.27391
Abstract: A mechanical stimulation plays a pivotal role in maintaining normal cartilage function. Our objective was to reveal the mechanism of action of the tension‐sensitive molecule miR‐455‐5p in the degeneration of endplate chondrocytes and to identify… read more here.
Keywords: mir 455; endplate chondrocytes; degeneration endplate; tgf smad ... See more keywords
circRNA_0058097 promotes tension‐induced degeneration of endplate chondrocytes by regulating HDAC4 expression through sponge adsorption of miR‐365a‐5p
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DOI: 10.1002/jcb.29202
Abstract: Excessive mechanical tension can lead to the degeneration of endplate chondrocytes. The presence of tension‐sensitive circRNA_0058097 molecules has been detected in human endplate chondrocytes, where it was found to be a potential competing endogenous RNA.… read more here.
Keywords: degeneration endplate; endplate chondrocytes; circrna 0058097; endplate ... See more keywords
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway
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DOI: 10.3389/fphar.2022.937502
Abstract: Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral disc degeneration (IVDD). Icariin (ICA) is the major active ingredient of Herba Epimedii and has various biological activities such as anti-inflammatory and… read more here.
Keywords: ica; degeneration; endplate chondrocytes; nrf pathway ... See more keywords