Late gadolinium enhancement and the risk of ventricular arrhythmias and sudden death in NYHA I patients with non-ischemic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of heart failure"
DOI: 10.1002/ejhf.2793
Abstract: AIMS To compare the risk of ventricular arrhythmias (VA) and sudden death (SD) between NYHA I and NYHA II-III patients with non-ischemic cardiomyopathy (NICM). METHODS AND RESULTS Observational retrospective cohort study including patients with NICM… read more here.
Keywords: nyha iii; endpoint; nyha patients; death ... See more keywords
Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints
Sign Up to like & getrecommendations! Published in 2025 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.70006
Abstract: The benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding… read more here.
Keywords: response; bmr values; endpoint; bmr ... See more keywords
The Win Ratio Approach in Bayesian Monitoring for Two‐Arm Phase II Clinical Trial Designs With Multiple Time‐To‐Event Endpoints
Sign Up to like & getrecommendations! Published in 2024 at "Statistics in Medicine"
DOI: 10.1002/sim.10282
Abstract: To assess the preliminary therapeutic impact of a novel treatment, futility monitoring is commonly employed in Phase II clinical trials to facilitate informed decisions regarding the early termination of trials. Given the rapid evolution in… read more here.
Keywords: event endpoints; time; time event; event ... See more keywords
Response‐Adaptive Randomization Procedure in Clinical Trials with Surrogate Endpoints
Sign Up to like & getrecommendations! Published in 2024 at "Statistics in Medicine"
DOI: 10.1002/sim.10286
Abstract: In clinical trials, subjects are usually recruited sequentially. According to the outcomes amassed thus far in a trial, the response‐adaptive randomization (RAR) design has been shown to be an advantageous treatment assignment procedure that skews… read more here.
Keywords: adaptive randomization; response adaptive; procedure; surrogate endpoints ... See more keywords
Sample size formula for a win ratio endpoint
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9297
Abstract: The win ratio composite endpoint, which organizes the components of the composite hierarchically, is becoming popular in late‐stage clinical trials. The method involves comparing data in a pair‐wise manner starting with the endpoint highest in… read more here.
Keywords: sample size; endpoint; win ratio; size ... See more keywords
What endpoints should be used for clinical studies in acute kidney injury?
Sign Up to like & getrecommendations! Published in 2017 at "Intensive Care Medicine"
DOI: 10.1007/s00134-017-4732-1
Abstract: Introduction Probably the easiest way to ruin a clinical trial is to choose the wrong endpoint. Our assessment as to whether something works in medicine, whether treatment or diagnostic, is based on “hitting” the primary… read more here.
Keywords: medicine; kidney injury; endpoint; endpoints used ... See more keywords
Solution to titration endpoint challenge
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01800-7
Abstract: This challenge invites us to think about the endpoint estimates in acid-base titration [1]. The purpose of titration is to establish the amount of a substance present in solution by chemically reacting that substance with… read more here.
Keywords: endpoint; titration endpoint; titration; challenge ... See more keywords
Improving categorical endpoint longitudinal exposure-response modeling through the joint modeling with a related endpoint.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmacokinetics and pharmacodynamics"
DOI: 10.1007/s10928-021-09796-3
Abstract: Exposure-response modeling is important to optimize dose and dosing regimens in clinical drug development. While primary clinical trial endpoints often have few categories and thus provide only limited information, sometimes there may be additional, more… read more here.
Keywords: response modeling; exposure response; endpoint; response ... See more keywords
Endothelin-1 in combination with CRB-65 enhance risk stratification in COVID-19 patients
Sign Up to like & getrecommendations! Published in 2025 at "Infection"
DOI: 10.1007/s15010-025-02627-4
Abstract: COVID-19 continuously causes severe disease conditions and significant mortality. We evaluate whether easily accessible biomarkers can improve risk prediction of severe disease outcomes. Our study analysed 426 COVID-19 patients collected by German CAPNETZ and PROGRESS… read more here.
Keywords: covid patients; risk; crb; prediction ... See more keywords
Interim monitoring in a treatment strategy trial with a composite primary endpoint.
Sign Up to like & getrecommendations! Published in 2019 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2019.105846
Abstract: When a clinical trial has a composite endpoint and a comparison of treatment strategies with multiple intervention components, interim data reviews by a data safety and monitoring board (DSMB) can be challenging as the data… read more here.
Keywords: trial; endpoint; treatment; study ... See more keywords
A systematic review of in-hospital worsening heart failure as an endpoint in clinical investigations of therapy for acute heart failure.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.10.023
Abstract: BACKGROUND In-hospital worsening heart failure (WHF) occurs frequently in patients hospitalized for acute heart failure (AHF) and has strongly negative prognostic associations. It may be a useful endpoint in studies of AHF management but important… read more here.
Keywords: hospital whf; failure; endpoint; heart failure ... See more keywords