Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling
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DOI: 10.1016/j.tetlet.2019.151123
Abstract: Abstract Atypical ubiquitin (Ub) chains are generally involved in intracellular physiological processes, while the molecular mechanisms underlying their regulation remain unclear. In this work, we report an acid-sensitive auxiliary group based bifunctional handle that can… read more here.
Keywords: sensitive auxiliary; thiol ene; assisted atypical; ene coupling ... See more keywords
Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling
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DOI: 10.1038/s42004-025-01412-6
Abstract: The thiol-ene reaction between an alkene and a thiol can be exploited for selective labelling of cysteine residues in protein profiling applications. Here, we explore thiol-ene activation in systems from chemical models to complex cellular… read more here.
Keywords: protein profiling; activation; thiol ene; protein ... See more keywords