Total Synthesis of Immunosuppressive Mycestericin E and G Enabled by a Highly Stereoselective Nitroso-Ene Cyclization.
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DOI: 10.1021/acs.orglett.3c01082
Abstract: This report describes a streamlined synthesis of immunosuppressive mycestericin E and G through a highly stereoselective nitroso-ene cyclization in 11-12 steps using readily available materials. The stereochemical outcome in the formation of a Nα-quaternary stereogenic… read more here.
Keywords: synthesis immunosuppressive; stereoselective nitroso; nitroso ene; highly stereoselective ... See more keywords
Enantio- and E-selective Carbonyl-Ene Cyclization of 5-Substituted 5-Hexenals Catalyzed by Tris(pentafluorophenyl)borane-Assisted Chiral Phosphoric Acids.
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DOI: 10.1021/acs.orglett.5c02136
Abstract: The enantio- and E-selective carbonyl-ene cyclization (6-endo-trig) of 5-substituted 5-hexanals has been achieved using a new Lewis-acid-assisted chiral Brønsted acid (LBA), i.e., a tris(pentafluorophenyl)borane-chiral phosphoric acid complex. The high enantioselectivity and E-selectivity are induced through… read more here.
Keywords: enantio selective; tris pentafluorophenyl; ene cyclization; carbonyl ene ... See more keywords