Type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3) inhibition and potential anti-proliferative activity of cholest-4-ene-3,6-dione in MCF-7 breast cancer cells
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DOI: 10.1016/j.steroids.2020.108638
Abstract: Cholest-4-ene-3,6-dione (KS) is a cholesterol oxidation product which exhibits anti-proliferative activity. However, its precise mechanism of action remains unknown. In this study, the effects of KS on AKR1C3 inhibition and anti-proliferative activities were investigated in… read more here.
Keywords: anti proliferative; cholest ene; mcf; inhibition ... See more keywords
A combined crystallographic and theoretical study of weak intermolecular interactions in crystalline squaric acid esters and amides
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DOI: 10.1039/c7ce00556c
Abstract: We report the synthesis and X-ray solid state structures of five squaric acid derivatives, i.e. a zwitterionic compound, namely 3-hydroxy-4-(2-pyridin-2-yl-ethylamino)cyclobut-3-ene-1,2-dione (1), a squaramide monoester, 3-ethoxy-4-(2-pyridin-2-yl-ethylamino)cyclobut-3-ene-1,2-dione (2), two differently solvated (EtOH and DMSO/water) disquaramides 3,4-bis((4-hydroxyphenethyl)amino)cyclobut-3-ene-1,2-dione (3… read more here.
Keywords: solid state; squaric acid; cyclobut ene; combined crystallographic ... See more keywords
Synthesis and crystal structures of (2E)-1,4-bis(4-chlorophenyl)but-2-ene-1,4-dione and (2E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione
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DOI: 10.1107/s205698901800230x
Abstract: The molecular structure of (2E)-1,4-bis(4-chlorophenyl)but-2-ene-1,4-dione (1) is composed of two p-chloro phenyl rings, each bonded on opposite ends to a near planar 1,4-trans enedione moiety [–C(= O)—CH=CH—(C=O)–]. (2E)-1,4-Bis(4-bromophenyl)but-2-ene-1,4-dione (2) has a similar structure to (1),… read more here.
Keywords: chlorophenyl ene; ene dione; bis chlorophenyl; dione ... See more keywords
Structures of three disubstituted [13]-macrodilactones reveal effects of substitution on macrocycle conformation
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DOI: 10.1107/s2056989020012037
Abstract: The synthesis and crystal structures of three new disubstituted [13]-macrodilactones, trans-4,8-dimethyl-1,10-dioxacyclotridec-5-ene-2,9-dione, cis-4-(4-bromophenyl)-13-methyl-1,10-dioxacyclotridec-5-ene-2,9-dione, and trans-11-methyl-4-phenyl-1,10-dioxacyclotridec-5-ene-2,9-dione are reported and their conformations are put in the context of other [13]-macrodilactone structures reported previously, showing that the number, location,… read more here.
Keywords: dioxacyclotridec ene; structures three; three disubstituted; disubstituted macrodilactones ... See more keywords