N-Heterocyclic Carbene-Catalyzed Umpolung of Cyclopent-4-ene-1,3-diones for Activated Olefin-Isatin Cross-Coupling.
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DOI: 10.1021/acs.orglett.2c02413
Abstract: N-Heterocyclic carbene (NHC)-catalyzed umpolung of cyclopent-4-ene-1,3-diones that proceeds via the generation of nucleophilic deoxy-Breslow intermediates is presented. The carbene generated from a commercially available thiazolium salt catalyzed the cross-coupling between cyclopent-4-ene-1,3-diones and isatins to furnish… read more here.
Keywords: umpolung cyclopent; catalyzed umpolung; cyclopent ene; ene diones ... See more keywords