Regio- and Stereoselective Addition to gem-Difluorinated Ene-Ynamides: Access to Stereodefined Fluorinated Dienes.
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DOI: 10.1021/acs.orglett.2c01593
Abstract: The first synthesis of gem-difluorinated ene-ynamides is presented via deprotonation of trifluoromethylated N-allenamides and δ extrusion of fluorine. These highly reactive building blocks, owing to their dual functional groups, offer a unique entry to difluorinated… read more here.
Keywords: addition; gem difluorinated; ene ynamides; difluorinated ene ... See more keywords
Highly Site-Selective Oxidative Cyclization of Ene-ynamides via Non-Noble-Metal Catalysis: Access to Functionalized Lactams.
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DOI: 10.1021/acs.orglett.2c02871
Abstract: Herein, an unprecedented non-noble-metal-catalyzed oxidation/cyclization of ene-ynamides is developed, allowing the synthesis of diversely functionalized lactams in moderate to good yields with excellent diastereoselectivities without the observation of typical cyclopropanation products. In combination with Ellman's… read more here.
Keywords: cyclization ene; functionalized lactams; ene ynamides; noble metal ... See more keywords