Linear free energy relationship analysis of permeability across polydimethylsiloxane (PDMS) membranes and comparison with human skin permeation in vitro
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DOI: 10.1016/j.ejps.2018.08.012
Abstract: ABSTRACT The aim of the present work is to evaluate the similarity between PDMS membranes and human skin in vitro in permeation study by linear free energy relationship (LFER) analyses. The values of the permeability… read more here.
Keywords: permeation; pdms membranes; energy relationship; human skin ... See more keywords
Biorelevant Drug Solubility Enhancement Modeled by a Linear Solvation Energy Relationship.
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DOI: 10.1016/j.xphs.2017.08.017
Abstract: It is for the pharmaceutical sciences of vital importance to understand how drugs are solubilized in biorelevant media. However, the complexity of fasted state simulated intestinal fluid (FaSSIF) has so far hampered adequate solubility modeling.… read more here.
Keywords: biorelevant drug; energy relationship; drug; solubility enhancement ... See more keywords