DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.
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DOI: 10.1172/jci.insight.94298
Abstract: Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8-/- mice have decreased… read more here.
Keywords: immune synapse; tregs; immunological tolerance; enforces immunological ... See more keywords