LAUSR

Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase V

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0 Published in 2020 at "ACS Catalysis"

DOI: 10.1021/acscatal.0c02222

Abstract: α-Mannoside β-1,6-N-acetylglucos­aminyl­transferase V (MGAT5) is a mammalian glycosyltransferase involved in complex N-glycan formation, which strongly drives cancer when overexpressed. Despite intense interest, the catalytic mechanism of MGAT5 is not known in detail, precluding therapeutic exploitation.… read more here.

Keywords: mgat5; engagement catalytic; catalytic mechanisms; mechanisms acetylglucosaminyltransferase ... See more keywords