Articles with "engaging lysosomal" as a keyword



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Emerging degrader technologies engaging lysosomal pathways

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Published in 2022 at "Chemical Society Reviews"

DOI: 10.1039/d2cs00624c

Abstract: Targeted protein degradation (TPD) provides unprecedented opportunities for drug discovery. While the proteolysis-targeting chimera (PROTAC) technology has already entered clinical trials and changed the landscape of small-molecule drugs, new degrader technologies harnessing alternative degradation machineries,… read more here.

Keywords: emerging degrader; degrader technologies; technologies engaging; lysosomal pathways ... See more keywords